N-tertbutyl-2-(5-(difluoromethoxy)-1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide

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Chemical Name:N-tertbutyl-2-(5-(difluoromethoxy)-1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide
CAS No.:1426425-62-8
Molecular Formula:C₄₅H₄₄F₂N₆O₄
Molecular Weight:770.879
Hs Code.:

N-tertbutyl-2-(5-(difluoromethoxy)-1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide

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Chemical Property of N-tertbutyl-2-(5-(difluoromethoxy)-1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide

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Technology Process of N-tertbutyl-2-(5-(difluoromethoxy)-1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide

There total 10 articles about N-tertbutyl-2-(5-(difluoromethoxy)-1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422773-01-0
N-tert-butyl 2-(5-(difluoromethoxy)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide

: 76099-47-3
rac-O-isopropylidene-3,4-dihydroxybutyl methanesulfonate

: 1426425-62-8
N-tertbutyl-2-(5-(difluoromethoxy)-1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 2h;
DOI:10.1021/jm301720p

Reference yield:

: 858661-78-6
5-(difluoromethoxy)-1H-indazole-3-carboxylic acid

: 1426425-62-8
N-tertbutyl-2-(5-(difluoromethoxy)-1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium iodide; sodium hydrogencarbonate; iodine / water; dichloromethane / 0.75 h / 100 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.33 h / -25 °C

2.2: 1.5 h / -25 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere; Sonication

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; isopropylmagnesium chloride; sodium hydrogencarbonate; potassium carbonate; sodium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm301720p

Reference yield:

: 1422772-70-0
5-(difluoromethoxy)-3-(tributylstannyl)-1H-indazole

: 1426425-62-8
N-tertbutyl-2-(5-(difluoromethoxy)-1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)-1H-indazol-3-yl)-5-trityl-5H-pyrrolo[3,2-b]pyrazine-7-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere; Sonication

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm301720p