(2S,3R)-5-Benzyloxy-2-hydroxy-3-methyl-pentanoic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:(2S,3R)-5-Benzyloxy-2-hydroxy-3-methyl-pentanoic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:108781-59-5
Molecular Formula:C₃₇H₄₇NO₆S
Molecular Weight:633.849
Hs Code.:

(2S,3R)-5-Benzyloxy-2-hydroxy-3-methyl-pentanoic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

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Chemical Property of (2S,3R)-5-Benzyloxy-2-hydroxy-3-methyl-pentanoic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

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Technology Process of (2S,3R)-5-Benzyloxy-2-hydroxy-3-methyl-pentanoic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 5 articles about (2S,3R)-5-Benzyloxy-2-hydroxy-3-methyl-pentanoic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 108781-56-2
(R)-5-Benzyloxy-3-methyl-pentanoic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

: 108781-59-5
(2S,3R)-5-Benzyloxy-2-hydroxy-3-methyl-pentanoic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; potassium hexamethylsilazane; potassium sec-butoxide; at -56 - -30 ℃; for 8h;
DOI:10.1016/S0040-4039(00)84894-7

Reference yield:

: 61898-55-3,97145-14-7
(4R)-4-methyltetrahydro-2H-pyran-2-one

: 108781-59-5
(2S,3R)-5-Benzyloxy-2-hydroxy-3-methyl-pentanoic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 5 steps

2: 1.) sodium hydride, 2.) tetrabutyl ammonium iodide

3: 99 percent / KOH / methanol

4: 65 percent / carbonyldiimidazole, sodium

5: 48 percent / MoO₅*Py*HMPT, KN(SiMe₃)2, K(sec-BuO) / 8 h / -56 - -30 °C

With potassium hydroxide; oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; sodium; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; potassium sec-butoxide; 1,1'-carbonyldiimidazole; In methanol;
DOI:10.1016/S0040-4039(00)84894-7

Reference yield:

: 108781-62-0
(R)-5-Benzyloxy-3-methyl-pentanoic acid benzyl ester

: 108781-59-5
(2S,3R)-5-Benzyloxy-2-hydroxy-3-methyl-pentanoic acid (1R,2S,3R,4S)-3-[benzenesulfonyl-(3,5-dimethyl-phenyl)-amino]-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / KOH / methanol

2: 65 percent / carbonyldiimidazole, sodium

3: 48 percent / MoO₅*Py*HMPT, KN(SiMe₃)2, K(sec-BuO) / 8 h / -56 - -30 °C

With potassium hydroxide; oxodiperoxymolybdenumpyridine hexamethylphosphoric triamide complex; sodium; potassium hexamethylsilazane; potassium sec-butoxide; 1,1'-carbonyldiimidazole; In methanol;
DOI:10.1016/S0040-4039(00)84894-7