3-(4-methylphenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one

Base Information

• Chemical Name: 3-(4-methylphenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one
• CAS No.: 1589532-61-5
• Molecular Formula: C₁₄H₁₄O₅S
• Molecular Weight: 294.328
• Mol file: 1589532-61-5.mol

Synonyms:

Chemical Property of 3-(4-methylphenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methylphenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one

There total 5 articles about 3-(4-methylphenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H14O3 (1589533-16-3) → 3-(4-methylphenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one (1589532-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / methanol / Reflux

2: triethylamine / dichloromethane / 0 °C

3: sodium hydroxide / N,N-dimethyl-formamide / 85 °C

With sodium methylate; triethylamine; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: |Aldol Condensation;

DOI:10.1016/j.bmcl.2014.03.012

Reference yield:

3-(4-methylphenyl)-5-(hydroxymethyl)-4-methoxyfuran-2(5H)-one (1589533-27-6) → 3-(4-methylphenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one (1589532-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 °C

2: sodium hydroxide / N,N-dimethyl-formamide / 85 °C

With triethylamine; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.03.012

Reference yield:

4-tolylacetic acid (622-47-9) → 3-(4-methylphenyl)-7a-methyl-7,7a-dihydrofuran[3,2-d][1,2]oxathin-5,5-dioxide-2(4H)-one (1589532-61-5)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine / toluene; tetrahydrofuran / Reflux

2: potassium tert-butylate / toluene; N,N-dimethyl-formamide / 0 - 20 °C

3: potassium carbonate / acetone

4: sodium methylate / methanol / Reflux

5: triethylamine / dichloromethane / 0 °C

6: sodium hydroxide / N,N-dimethyl-formamide / 85 °C

With potassium tert-butylate; sodium methylate; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; 4: |Aldol Condensation;

DOI:10.1016/j.bmcl.2014.03.012

upstream raw materials:

C₁₃H₁₄O₃

3-(4-methylphenyl)-5-(hydroxymethyl)-4-methoxyfuran-2(5H)-one

4-tolylacetic acid

C₁₄H₁₈O₄