16,16-Dimethylprostaglandin E2 methyl ester

Base Information

Chemical Name:16,16-Dimethylprostaglandin E2 methyl ester
CAS No.:42782-96-7
Deprecated CAS:59285-87-9
Molecular Formula:C23H38 O5
Molecular Weight:394.552
Hs Code.:

Synonyms:16,16-Dimethylprostaglandin E2 methyl ester;42782-96-7;16,16-Dimethyl-pge2 methyl ester

Suppliers and Price of 16,16-Dimethylprostaglandin E2 methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 16,16-Dimethylprostaglandin E2 methyl ester

Chemical Property:

Vapor Pressure:1.98E-12mmHg at 25°C
Boiling Point:507.6°C at 760 mmHg
Flash Point:162.7°C
Density:1.08g/cm³
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:13
Exact Mass:394.27192431
Heavy Atom Count:28
Complexity:549

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC(C)(C)C(C=CC1C(CC(=O)C1CC=CCCCC(=O)OC)O)O
Isomeric SMILES:CCCCC(C)(C)C(/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)OC)O)O

Technology Process of 16,16-Dimethylprostaglandin E2 methyl ester

There total 12 articles about 16,16-Dimethylprostaglandin E2 methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3R)-2-(1,1-Dimethyl-pentyl)-3-iodomethyl-oxirane

: 42782-96-7
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(R)-3-hydroxy-4,4-dimethyl-oct-1-enyl)-5-oxo-cyclopentyl]-hept-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: KN(SiMe₃)2 / 18-crown-6 / tetrahydrofuran; toluene / 48 h / -78 °C

2: imidazole, Et₃N / dimethylformamide / 4 h / 20 °C

3: 1.6 M nBuLi, CuCN, 1.5 M MeLi / diethyl ether; hexane / 0.33 h / -78 °C

4: pyridinium p-toluenesulfonate / acetone; H₂O / 4 h / Ambient temperature

With 1H-imidazole; n-butyllithium; methyllithium; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; triethylamine; 18-crown-6 ether; In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1002/(SICI)1521-4184(19989)331:9<279::AID-ARDP279>3.0.CO;2-3

Reference yield:

: [(2S,3S)-3-(1,1-Dimethyl-pentyl)-oxiranyl]-methanol

: 42782-96-7
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(R)-3-hydroxy-4,4-dimethyl-oct-1-enyl)-5-oxo-cyclopentyl]-hept-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: PPh₃, imidazole, iPr₂NEt, I₂ / acetonitrile; diethyl ether / 1 h / Ambient temperature

2: KN(SiMe₃)2 / 18-crown-6 / tetrahydrofuran; toluene / 48 h / -78 °C

3: imidazole, Et₃N / dimethylformamide / 4 h / 20 °C

4: 1.6 M nBuLi, CuCN, 1.5 M MeLi / diethyl ether; hexane / 0.33 h / -78 °C

5: pyridinium p-toluenesulfonate / acetone; H₂O / 4 h / Ambient temperature

With 1H-imidazole; n-butyllithium; methyllithium; iodine; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 18-crown-6 ether; In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1002/(SICI)1521-4184(19989)331:9<279::AID-ARDP279>3.0.CO;2-3

Reference yield:

: 61263-34-1
(Z)-7-[(1R,2R,3R)-2-((E)-(R)-4,4-Dimethyl-3-trimethylsilanyloxy-oct-1-enyl)-5-oxo-3-trimethylsilanyloxy-cyclopentyl]-hept-5-enoic acid methyl ester

: 42782-96-7
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(R)-3-hydroxy-4,4-dimethyl-oct-1-enyl)-5-oxo-cyclopentyl]-hept-5-enoic acid methyl ester

Guidance literature:: With pyridinium p-toluenesulfonate; In water; acetone; for 4h; Yield given; Ambient temperature;
DOI:10.1002/(SICI)1521-4184(19989)331:9<279::AID-ARDP279>3.0.CO;2-3