methyl (δR,1R,3aS,4E,7R,7aR)-4-{(2Z)-2-{(3S,5R)-3,5-bis{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-methylenecyclohexylidene}ethylidene}octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate

Base Information

Chemical Name:methyl (δR,1R,3aS,4E,7R,7aR)-4-{(2Z)-2-{(3S,5R)-3,5-bis{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-methylenecyclohexylidene}ethylidene}octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate
CAS No.:1412439-02-1
Molecular Formula:C₄₇H₈₆O₅Si₂
Molecular Weight:787.368
Hs Code.:

methyl (δR,1R,3aS,4E,7R,7aR)-4-{(2Z)-2-{(3S,5R)-3,5-bis{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-methylenecyclohexylidene}ethylidene}octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate

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Chemical Property of methyl (δR,1R,3aS,4E,7R,7aR)-4-{(2Z)-2-{(3S,5R)-3,5-bis{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-methylenecyclohexylidene}ethylidene}octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate

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Technology Process of methyl (δR,1R,3aS,4E,7R,7aR)-4-{(2Z)-2-{(3S,5R)-3,5-bis{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-methylenecyclohexylidene}ethylidene}octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate

There total 5 articles about methyl (δR,1R,3aS,4E,7R,7aR)-4-{(2Z)-2-{(3S,5R)-3,5-bis{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-methylenecyclohexylidene}ethylidene}octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1412439-01-0
methyl (δR,1R,3aS,4E,7R,7aR)-octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl4-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]-1H-indene-1-pentanoate

: 191849-74-8
Trifluoro-methanesulfonic acid (2S,4R)-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-1-methylene-hept-6-ynyl ester

: 1412439-02-1
methyl (δR,1R,3aS,4E,7R,7aR)-4-{(2Z)-2-{(3S,5R)-3,5-bis{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-methylenecyclohexylidene}ethylidene}octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate

Guidance literature:: methyl (δR,1R,3aS,4E,7R,7aR)-octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl4-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]-1H-indene-1-pentanoate; Trifluoro-methanesulfonic acid (2S,4R)-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-1-methylene-hept-6-ynyl ester; With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In tetrahydrofuran; for 1h; Inert atmosphere; Darkness;

With water; In tetrahydrofuran; Inert atmosphere;
DOI:10.1002/hlca.201200427

Reference yield:

: 1412438-97-1
7-((3R,3aR,4R,7S,7aR)-octahydro-3-[(1S)-2-iodo-1-methylethyl]-3a-methyl-1H-indene-4-yl)-α,α-dimethylheptanol

: 1412439-02-1
methyl (δR,1R,3aS,4E,7R,7aR)-4-{(2Z)-2-{(3S,5R)-3,5-bis{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-methylenecyclohexylidene}ethylidene}octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; zinc; nickel(II) chloride hexahydrate / 2 h / 60 °C / Inert atmosphere

1.2: 0.33 h / 20 °C / Inert atmosphere

2.1: Dess-Martin periodane / dichloromethane / 1 h / Inert atmosphere; Darkness

3.1: tetrahydrofuran; toluene / 5 h / -17 - 20 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tricyclohexylphosphine; potassium acetate / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

5.1: potassium phosphate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / Inert atmosphere; Darkness

5.2: Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; nickel(II) chloride hexahydrate; potassium acetate; Dess-Martin periodane; zinc; tricyclohexylphosphine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; 3.1: |Wittig Olefination / 5.1: |Suzuki-Miyaura Coupling;
DOI:10.1002/hlca.201200427

Reference yield:

: 1412439-00-9
methyl (δR,1R,3aR,4E,7R,7aR)-4-(bromomethylene)octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate

: 1412439-02-1
methyl (δR,1R,3aS,4E,7R,7aR)-4-{(2Z)-2-{(3S,5R)-3,5-bis{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-methylenecyclohexylidene}ethylidene}octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tricyclohexylphosphine; potassium acetate / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

2.1: potassium phosphate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / Inert atmosphere; Darkness

2.2: Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; tricyclohexylphosphine; In tetrahydrofuran; dimethyl sulfoxide; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1002/hlca.201200427