N-(carbobenzyloxy)-5-fluoro-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:N-(carbobenzyloxy)-5-fluoro-1,2,3,4-tetrahydroisoquinoline
CAS No.:123594-08-1
Molecular Formula:C₁₇H₁₆FNO₂
Molecular Weight:285.318
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(carbobenzyloxy)-5-fluoro-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of N-(carbobenzyloxy)-5-fluoro-1,2,3,4-tetrahydroisoquinoline

There total 3 articles about N-(carbobenzyloxy)-5-fluoro-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41959-45-9
5-nitro-1,2,3,4-tetrahydroisoquinoline

: 123594-08-1
N-(carbobenzyloxy)-5-fluoro-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: aq. K₂CO₃ / ethyl acetate

2: 97 percent / stannous chloride dihydrate, 10percent HCl / acetic acid / 48 h / Ambient temperature

3: 1.) boron trifluoride etherate, tert-butyl nitrite / 1.) methylene dichloride, from -15 deg C to 3 deg C, 25 min, 2.) pentane, room temp., 72 h

With hydrogenchloride; tert.-butylnitrite; boron trifluoride diethyl etherate; potassium carbonate; tin(ll) chloride; In acetic acid; ethyl acetate;
DOI:10.1021/jm00164a021

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 123594-08-1
N-(carbobenzyloxy)-5-fluoro-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: aq. K₂CO₃ / ethyl acetate

2: 97 percent / stannous chloride dihydrate, 10percent HCl / acetic acid / 48 h / Ambient temperature

3: 1.) boron trifluoride etherate, tert-butyl nitrite / 1.) methylene dichloride, from -15 deg C to 3 deg C, 25 min, 2.) pentane, room temp., 72 h

With hydrogenchloride; tert.-butylnitrite; boron trifluoride diethyl etherate; potassium carbonate; tin(ll) chloride; In acetic acid; ethyl acetate;
DOI:10.1021/jm00164a021

Reference yield:

: 123594-07-0
5-amino-3,4-dihydroisoquinoline-2(H)-carboxylic acid benzyl ester ester

: 123594-08-1
N-(carbobenzyloxy)-5-fluoro-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With tert.-butylnitrite; boron trifluoride diethyl etherate; Yield given. Multistep reaction; 1.) methylene dichloride, from -15 deg C to 3 deg C, 25 min, 2.) pentane, room temp., 72 h;
DOI:10.1021/jm00164a021