Technology Process of triethyl 6-(4-oxocyclohex-2-enyl)hex-1-yne-1,5,5-tricarboxylate
There total 6 articles about triethyl 6-(4-oxocyclohex-2-enyl)hex-1-yne-1,5,5-tricarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
water; acetone;
at 0 - 20 ℃;
DOI:10.1021/jo301554z
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 30 h / -78 - -70 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
3.2: 0 - 100 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
4.2: 0 - 50 °C / Inert atmosphere
5.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
5.2: -78 - 20 °C / Inert atmosphere
6.1: toluene-4-sulfonic acid / acetone; water / 0 - 20 °C
With
dmap; trimethylsilyl trifluoromethanesulfonate; sodium hydride; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo301554z
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid / acetone; water / 0 - 20 °C
With
toluene-4-sulfonic acid; lithium diisopropyl amide;
In
tetrahydrofuran; water; acetone;
DOI:10.1021/jo301554z
