neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide

Base Information

Chemical Name:neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide
CAS No.:1285527-15-2
Molecular Formula:C₃₇H₆₁N₇O₁₂S
Molecular Weight:827.997
Hs Code.:

neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide

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Chemical Property of neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide

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Technology Process of neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide

There total 8 articles about neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₆H₆₈N₆O₁₀S₂

: 220874-82-8
N-6'-bromoacetylneamine

: 1285527-15-2
neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide

Guidance literature:: C₄₆H₆₈N₆O₁₀S₂; With N-ethyl-N,N-diisopropylamine; D/L-dithiothreitol; In water; acetone; for 0.0333333h; Sonication;

N-6'-bromoacetylneamine; In water; acetone; at 20 ℃; for 16.0333h; Sonication;
DOI:10.1039/c0ob01018a

Reference yield:

: C₅₈H₉₆N₆O₁₀S₂Si₂

: 1285527-15-2
neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; D/L-dithiothreitol / water; acetone / 0.03 h / Sonication

2.2: 16.03 h / 20 °C / Sonication

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; D/L-dithiothreitol; In tetrahydrofuran; water; acetone;
DOI:10.1039/c0ob01018a

Reference yield:

: 1285527-19-6
C₃₄H₆₆N₄O₈S₂Si₂

: 1285527-15-2
neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium sulfate / 1,2-dichloro-ethane / 1 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 16 h / 20 °C

3.1: 2-hydroxypyridin / tetrahydrofuran / 16 h / 50 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; D/L-dithiothreitol / water; acetone / 0.03 h / Sonication

5.2: 16.03 h / 20 °C / Sonication

With 2-hydroxypyridin; sodium tetrahydroborate; tetrabutyl ammonium fluoride; sodium sulfate; N-ethyl-N,N-diisopropylamine; D/L-dithiothreitol; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane; acetone;
DOI:10.1039/c0ob01018a