N-<2-(4-dimethylaminophenyl)-6-phenylbenzyl>benzimidoyl chloride

Base Information

• Chemical Name: N-<2-(4-dimethylaminophenyl)-6-phenylbenzyl>benzimidoyl chloride
• CAS No.: 172976-12-4
• Molecular Formula: C₂₈H₂₅ClN₂
• Molecular Weight: 424.973
• Mol file: 172976-12-4.mol

Synonyms:

Chemical Property of N-<2-(4-dimethylaminophenyl)-6-phenylbenzyl>benzimidoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-(4-dimethylaminophenyl)-6-phenylbenzyl>benzimidoyl chloride

There total 8 articles about N-<2-(4-dimethylaminophenyl)-6-phenylbenzyl>benzimidoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-6-nitrotoluene (55289-35-5) → N-<2-(4-dimethylaminophenyl)-6-phenylbenzyl>benzimidoyl chloride (172976-12-4)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2.) sodium carbonate / 1.) 1,2-dimethoxyethane, 20 min, 2.) 1,2-dimethoxyethane, water, reflux

2: 100 percent / hydrogen / Pd/C / ethanol / 1810.02 Torr

4: 99 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

5: 80 percent / dimethylformamide / Ambient temperature

6: 92 percent / hydrazine hydrate / methanol / 1 h / Heating

7: 73 percent / sodium carbonate / CH₂Cl₂ / Ambient temperature

8: 1.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2.) sodium carbonate / 1.) 1,2-dimethoxyethane, 20 min, 2.) 1,2-dimethoxyethane, water, reflux, 45 min

9: chlorodimethylformiminium chloride / SOCl₂ / Ambient temperature

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Perbenzoic acid; Vilsmeier reagent; hydrogen; sodium carbonate; hydrazine hydrate; palladium on activated charcoal; In methanol; tetrachloromethane; thionyl chloride; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2-nitro-6-phenyltoluene (107622-50-4) → N-<2-(4-dimethylaminophenyl)-6-phenylbenzyl>benzimidoyl chloride (172976-12-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 100 percent / hydrogen / Pd/C / ethanol / 1810.02 Torr

3: 99 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

4: 80 percent / dimethylformamide / Ambient temperature

5: 92 percent / hydrazine hydrate / methanol / 1 h / Heating

6: 73 percent / sodium carbonate / CH₂Cl₂ / Ambient temperature

7: 1.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2.) sodium carbonate / 1.) 1,2-dimethoxyethane, 20 min, 2.) 1,2-dimethoxyethane, water, reflux, 45 min

8: chlorodimethylformiminium chloride / SOCl₂ / Ambient temperature

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Perbenzoic acid; Vilsmeier reagent; hydrogen; sodium carbonate; hydrazine hydrate; palladium on activated charcoal; In methanol; tetrachloromethane; thionyl chloride; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

3-nitro-o-tolylamine (603-83-8) → N-<2-(4-dimethylaminophenyl)-6-phenylbenzyl>benzimidoyl chloride (172976-12-4)

Guidance literature:

Multi-step reaction with 10 steps

1: 1.) NaNO₂, HBr, 2.) CuBr

2: 1.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2.) sodium carbonate / 1.) 1,2-dimethoxyethane, 20 min, 2.) 1,2-dimethoxyethane, water, reflux

3: 100 percent / hydrogen / Pd/C / ethanol / 1810.02 Torr

5: 99 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

6: 80 percent / dimethylformamide / Ambient temperature

7: 92 percent / hydrazine hydrate / methanol / 1 h / Heating

8: 73 percent / sodium carbonate / CH₂Cl₂ / Ambient temperature

9: 1.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2.) sodium carbonate / 1.) 1,2-dimethoxyethane, 20 min, 2.) 1,2-dimethoxyethane, water, reflux, 45 min

10: chlorodimethylformiminium chloride / SOCl₂ / Ambient temperature

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Perbenzoic acid; Vilsmeier reagent; hydrogen bromide; hydrogen; sodium carbonate; hydrazine hydrate; copper(I) bromide; sodium nitrite; palladium on activated charcoal; In methanol; tetrachloromethane; thionyl chloride; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-bromo-6-nitrotoluene

2-nitro-6-phenyltoluene

3-nitro-o-tolylamine

3-bromo-2-methyl-1,1′-biphenyl

Refernces