Technology Process of C22H22F9N5O3
There total 5 articles about C22H22F9N5O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 24h;
DOI:10.1016/j.tet.2012.07.069
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide; water / tetrahydrofuran / 21 h / 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 80 °C
With
water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.07.069
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen; 10% Pd/C / ethyl acetate / 6 h / 20 °C
2.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 3 h / 90 °C
2.2: 2.5 h / 0 - 20 °C
3.1: lithium hydroxide; water / tetrahydrofuran / 21 h / 20 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 80 °C
With
diphenyl phosphoryl azide; 10% Pd/C; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide;
In
tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.07.069
