2',4'-Dihydroxy-2-methoxyacetophenone

Base Information

• Chemical Name: 2',4'-Dihydroxy-2-methoxyacetophenone
• CAS No.: 57280-75-8
• Molecular Formula: C9H10 O4
• Molecular Weight: 182.176
• Hs Code.: 2914509090
• European Community (EC) Number: 661-712-0
• DSSTox Substance ID: DTXSID0069171
• Nikkaji Number: J429.339H
• Wikidata: Q81995980
• Mol file: 57280-75-8.mol

Synonyms:57280-75-8;1-(2,4-dihydroxyphenyl)-2-methoxyethanone;1-(2,4-dihydroxyphenyl)-2-methoxyethan-1-one;2',4'-Dihydroxy-2-methoxyacetophenone;Ethanone, 1-(2,4-dihydroxyphenyl)-2-methoxy-;SCHEMBL8462162;DTXSID0069171;MFCD00100481;AKOS022641003;PS-4194;CS-0186215;E76606

Chemical Property of 2',4'-Dihydroxy-2-methoxyacetophenone

Chemical Property:

• Vapor Pressure: 1.28E-05mmHg at 25°C
• Melting Point: 138–139°C
• Boiling Point: 358°Cat760mmHg
• Flash Point: 146.9°C
• PSA: 66.76000
• Density: 1.294g/cm³
• LogP: 0.92690
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 182.05790880
• Heavy Atom Count: 13
• Complexity: 181

Purity/Quality:

98%Min ^*data from raw suppliers

2',4'-Dihydroxy-2-methoxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(=O)C1=C(C=C(C=C1)O)O

Technology Process of 2',4'-Dihydroxy-2-methoxyacetophenone

There total 4 articles about 2',4'-Dihydroxy-2-methoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Methoxyethansaeure-phenylester (16839-92-2) + recorcinol (108-46-3) → 2',4'-dihydroxy-2-methoxyacetophenone (57280-75-8)

Guidance literature:

With P_. protegens acyltransferase F₁₄₈V; In aq. phosphate buffer; at 35 ℃; for 24h; Temperature;

DOI:10.1021/acscatal.9b04617

Reference yield: 48.0%

2-methoxyacetonitrile (1738-36-9) + recorcinol (108-46-3) → 2',4'-dihydroxy-2-methoxyacetophenone (57280-75-8)

Guidance literature:

2-methoxyacetonitrile; recorcinol; With hydrogenchloride; zinc(II) chloride; In diethyl ether; for 2h;

In water; for 1h; Heating;

DOI:10.1016/j.bmc.2004.02.031

Reference yield:

→ 2',4'-dihydroxy-2-methoxyacetophenone (57280-75-8)

Guidance literature:

With water; at 80 ℃;

upstream raw materials:

diazomethane

2,4-diacetoxybenzoyl chloride

2-methoxyacetonitrile

recorcinol

Downstream raw materials:

1-(4-allyloxy-2-hydroxy-phenyl)-2-methoxy-ethanone

1-(2,4-bis-allyloxy-phenyl)-2-methoxy-ethanone

2'-Chloro-7-hydroxy-3-methoxy-flavone

5'-Chloro-7-hydroxy-3,2'-dimethoxyflavone