Technology Process of 3-difluoromethyl-3-(3-benzyloxyphenyl)propionic acid
There total 9 articles about 3-difluoromethyl-3-(3-benzyloxyphenyl)propionic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dipyridinium dichromate;
In
N,N-dimethyl-formamide;
for 15h;
Yield given;
Ambient temperature;
DOI:10.1016/S0040-4039(00)73168-6
- Guidance literature:
-
Multi-step reaction with 9 steps
1: LiN(Si(CH3)3)2 / tetrahydrofuran / 1 h / 0 deg C to RT
2: diisobutylaluminum hydride / toluene / 1 h / Ambient temperature
3: 85 percent / propionic acid / 2 h / 135 °C
4: diisobutylaluminum hydride / toluene / 1 h / Ambient temperature
5: DMAP, Et3N / tetrahydrofuran / 1 h / Ambient temperature
6: O3, Ph3P / CH2Cl2; methanol / -70 deg C to RT
7: diethylaminosulfur trifluoride / CH2Cl2 / 1 h / Ambient temperature
8: K2CO3 / methanol / 1 h / Ambient temperature
9: pyridinium dichromate / dimethylformamide / 15 h / Ambient temperature
With
dmap; dipyridinium dichromate; diethylamino-sulfur trifluoride; diisobutylaluminium hydride; potassium carbonate; ozone; triethylamine; triphenylphosphine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; propionic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)73168-6
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 85 percent / propionic acid / 2 h / 135 °C
2: diisobutylaluminum hydride / toluene / 1 h / Ambient temperature
3: DMAP, Et3N / tetrahydrofuran / 1 h / Ambient temperature
4: O3, Ph3P / CH2Cl2; methanol / -70 deg C to RT
5: diethylaminosulfur trifluoride / CH2Cl2 / 1 h / Ambient temperature
6: K2CO3 / methanol / 1 h / Ambient temperature
7: pyridinium dichromate / dimethylformamide / 15 h / Ambient temperature
With
dmap; dipyridinium dichromate; diethylamino-sulfur trifluoride; diisobutylaluminium hydride; potassium carbonate; ozone; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; propionic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)73168-6
