Technology Process of PI-090
There total 11 articles about PI-090 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
2: 1H-imidazole / N,N-dimethyl-formamide / 80 °C
3: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -78 - -40 °C
4: lithium diisopropyl amide / tetrahydrofuran / -78 °C
5: palladium on activated charcoal / dichloromethane; N,N-dimethyl-formamide / 20 °C / Molecular sieve
6: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
7: dihydrogen peroxide; ammonium chloride / dichloromethane; water / 0 °C
8: trifluoroacetic acid / dichloromethane; water / 0 °C
With
1H-imidazole; lithium aluminium tetrahydride; oxalyl dichloride; palladium on activated charcoal; dihydrogen peroxide; ammonium chloride; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
3: Swern oxidation / 4: Aldol reaction;
DOI:10.1016/j.bmcl.2012.05.065
- Guidance literature:
-
Multi-step reaction with 6 steps
1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -78 - -40 °C
2: lithium diisopropyl amide / tetrahydrofuran / -78 °C
3: palladium on activated charcoal / dichloromethane; N,N-dimethyl-formamide / 20 °C / Molecular sieve
4: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
5: dihydrogen peroxide; ammonium chloride / dichloromethane; water / 0 °C
6: trifluoroacetic acid / dichloromethane; water / 0 °C
With
oxalyl dichloride; palladium on activated charcoal; dihydrogen peroxide; ammonium chloride; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
1: Swern oxidation / 2: Aldol reaction;
DOI:10.1016/j.bmcl.2012.05.065
