(R)-N-methyl-1,2,3,4-tetrahydroquinolin-3-amine maleate

Base Information

• Chemical Name: (R)-N-methyl-1,2,3,4-tetrahydroquinolin-3-amine maleate
• CAS No.: 166742-97-8
• Molecular Formula: C₄H₄O₄*C₁₀H₁₄N₂
• Molecular Weight: 278.308
• Mol file: 166742-97-8.mol

Synonyms:(R)-N-methyl-1,2,3,4-tetrahydroquinolin-3-amine maleate;166742-97-8;(Z)-but-2-enedioic acid;(3R)-N-methyl-1,2,3,4-tetrahydroquinolin-3-amine;SCHEMBL4803444;TUXOXFWHJLDLHG-YLGLLLDBSA-N;CS-M3644;AKOS037650638;CS-15106;(r)-3-methylamino-1,2,3,4-tetrahydroquinoline maleate;(R)-N-methyl-1,2,3,4-tetrahydroquinolin-3-aminemaleate

Chemical Property of (R)-N-methyl-1,2,3,4-tetrahydroquinolin-3-amine maleate

Chemical Property:

• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 278.12665706
• Heavy Atom Count: 20
• Complexity: 266

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNC1CC2=CC=CC=C2NC1.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: CN[C@@H]1CC2=CC=CC=C2NC1.C(=C\C(=O)O)\C(=O)O

Technology Process of (R)-N-methyl-1,2,3,4-tetrahydroquinolin-3-amine maleate

There total 1 articles about (R)-N-methyl-1,2,3,4-tetrahydroquinolin-3-amine maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (R)-3-Methylamino-1,2,3,4-tetrahydroquinoline maleate (166742-97-8)

Guidance literature:

Reference yield:

(R)-3-Methylamino-1,2,3,4-tetrahydroquinoline maleate (166742-97-8) → (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]-quinolin-2(1H)-one (179386-43-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 17.2 g / toluene / 0.5 h / -40 °C

2: triethylamine; tetrahydrofuran; toluene / 24 h / 0 °C

3: 5.13 g / triethylamine; tetrahydrofuran; toluene / 48 h / Ambient temperature

4: 0.41 g / PhI(OCOCF₃)2 / CHCl₃ / 6 h / -5 - 25 °C

5: 2.2 g / H₂ / Pd(OH)2/C / ethanol / 19 h / 2585.7 Torr

With hydrogen; bis-[(trifluoroacetoxy)iodo]benzene; palladium dihydroxide; In tetrahydrofuran; ethanol; chloroform; triethylamine; toluene;

DOI:10.1021/jo970526a

Reference yield:

(R)-3-Methylamino-1,2,3,4-tetrahydroquinoline maleate (166742-97-8) → ((R)-1-Chlorocarbonyl-1,2,3,4-tetrahydro-quinolin-3-yl)-methyl-carbamic acid benzyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 17.2 g / toluene / 0.5 h / -40 °C

2: triethylamine; tetrahydrofuran; toluene / 24 h / 0 °C

In tetrahydrofuran; triethylamine; toluene;

DOI:10.1021/jo970526a

Downstream raw materials:

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]-quinolin-2(1H)-one

((R)-1-Methoxycarbamoyl-1,2,3,4-tetrahydro-quinolin-3-yl)-methyl-carbamic acid benzyl ester