3-(4-Methoxyphenyl)-1-adamantanemethylamine

Base Information

• Chemical Name: 3-(4-Methoxyphenyl)-1-adamantanemethylamine
• CAS No.: 117077-70-0
• Molecular Formula: C₁₈H₂₅NO
• Molecular Weight: 271.403
• Mol file: 117077-70-0.mol

Synonyms:

Chemical Property of 3-(4-Methoxyphenyl)-1-adamantanemethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Methoxyphenyl)-1-adamantanemethylamine

There total 3 articles about 3-(4-Methoxyphenyl)-1-adamantanemethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-methoxyphenyl)adamantane-1-carboxylic acid (56531-56-7) → 3-(4-Methoxyphenyl)-1-adamantanemethylamine (117077-70-0)

Guidance literature:

Multi-step reaction with 3 steps

1: PCl₅ / CCl₄ / 1 h / Heating

2: ammonium hydroxide / tetrahydrofuran / 15 h

3: LiAlH₄ / 12 h / Heating

With ammonium hydroxide; lithium aluminium tetrahydride; phosphorus pentachloride; In tetrahydrofuran; tetrachloromethane;

DOI:10.1021/je00036a037

Reference yield:

3-(4-Methoxy-phenyl)-adamantane-1-carbonyl chloride (341496-73-9) → 3-(4-Methoxyphenyl)-1-adamantanemethylamine (117077-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / tetrahydrofuran / 15 h

2: LiAlH₄ / 12 h / Heating

With ammonium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/je00036a037

Reference yield:

3-(4-Methoxyphenyl)-1-adamantanecarboxamide (61051-24-9) → 3-(4-Methoxyphenyl)-1-adamantanemethylamine (117077-70-0)

Guidance literature:

With lithium aluminium tetrahydride; for 12h; Yield given; Heating;

DOI:10.1021/je00036a037

upstream raw materials:

3-(4-Methoxyphenyl)-1-adamantanecarboxamide

3-(4-methoxyphenyl)adamantane-1-carboxylic acid

3-(4-Methoxy-phenyl)-adamantane-1-carbonyl chloride