L-GlutaMic-2-13C Acid

Base Information

• Chemical Name: L-GlutaMic-2-13C Acid
• CAS No.: 133883-00-8
• Molecular Formula: C₅H₉NO₄
• Molecular Weight: 148.12
• Mol file: 133883-00-8.mol

Synonyms:

Chemical Property of L-GlutaMic-2-13C Acid

Chemical Property:

• Storage Temp.: Refrigerator

Purity/Quality:

98% by HPLC; 99% atom 13C ^*data from raw suppliers

L-Glutamic-2-13CAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Glutamic-2-13C Acid is an isotope labelled derivative of L-Glutamic Acid (G596960), a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. It is also a key molecule in cellular metabolism.

Technology Process of L-GlutaMic-2-13C Acid

There total 1 articles about L-GlutaMic-2-13C Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

<3-13C>-L-alanine (131157-42-1,133665-48-2,65163-25-9) → [2-13C]-L-glutamic acid (133883-00-8,108395-12-6)

Guidance literature:

In water; at 27 ℃; for 2.5h; Mechanism; metabolism, metabolic rate in vivo (Gryllodes sigillatus);

DOI:10.1248/cpb.39.210

Reference yield:

[2-13C]-L-glutamic acid (133883-00-8,108395-12-6) → edatrexate (2-13C-glutamic acid)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / HCl / 3 h / Heating

2: 1.) Et₃N, benzotriazole oxophosphonate / 1.) DMF, RT, 1.5 h, 2.) DMF, RT, 20 h

3: 44 percent / 1.25 N aq. NaOH / 2-methoxy-ethanol / 2.75 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; benzotriazole oxophosphonate; triethylamine; In 2-methoxy-ethanol;

DOI:10.1002/(SICI)1099-1344(199702)39:2<99::AID-JLCR949>3.0.CO;2-#

upstream raw materials:

<3-13C>-L-alanine