BOC-PheΨGly-LeuΨVal-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Base Information

Chemical Name:BOC-PheΨGly-LeuΨVal-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide
CAS No.:136630-76-7
Molecular Formula:C₄₁H₆₅N₇O₇S
Molecular Weight:800.076
Hs Code.:

BOC-PheΨ<COCH2S>Gly-LeuΨ<CHOHCH2>Val-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of BOC-PheΨGly-LeuΨVal-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

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Technology Process of BOC-PheΨGly-LeuΨVal-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

There total 5 articles about BOC-PheΨGly-LeuΨVal-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 136630-76-7
BOC-PheΨGly-LeuΨVal-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine (NMM) / ethyl acetate / 0.17 h / -10 °C

2: diethyl ether / 3 h / Ambient temperature

3: 47percent aq. HBr / dioxane / 1 h / 0 °C

4: 1.) NaOMe / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 1 h

5: N-NMM, 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With 4-methyl-morpholine; hydrogen bromide; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a016

Reference yield:

: 68709-71-7
tert-butyl 4-bromo-3-oxo-1-phenylbutan-2-ylcarbamate

: 136630-76-7
BOC-PheΨGly-LeuΨVal-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaOMe / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 1 h

2: N-NMM, 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00115a016

Reference yield:

: 60398-41-6
(3S)-tert-butyl 1-benzyl-3-diazo-2-oxopropylcarbamate

: 136630-76-7
BOC-PheΨGly-LeuΨVal-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: Multi-step reaction with 3 steps

1: 47percent aq. HBr / dioxane / 1 h / 0 °C

2: 1.) NaOMe / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 1 h

3: N-NMM, 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With hydrogen bromide; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a016