Boc-Tyr-Arg(NO₂)-Lys(Z)-Asp(OBzl)-D-Val-OBu^t

Base Information

Chemical Name:Boc-Tyr-Arg(NO₂)-Lys(Z)-Asp(OBzl)-D-Val-OBu^t
CAS No.:96356-56-8
Molecular Formula:C₅₄H₇₆N₁₀O₁₅
Molecular Weight:1105.26
Hs Code.:

Boc-Tyr-Arg(NO<sub>2</sub>)-Lys(Z)-Asp(OBzl)-D-Val-OBu<sup>t</sup>

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Chemical Property of Boc-Tyr-Arg(NO₂)-Lys(Z)-Asp(OBzl)-D-Val-OBu^t

Chemical Property:

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Technology Process of Boc-Tyr-Arg(NO₂)-Lys(Z)-Asp(OBzl)-D-Val-OBu^t

There total 9 articles about Boc-Tyr-Arg(NO₂)-Lys(Z)-Asp(OBzl)-D-Val-OBu^t which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 96356-53-5
H-Asp(OBzl)-D-Val-OBu^t*TFA

: 96356-49-9
Boc-Tyr-Arg(NO₂)-Lys(Z)-OH

: 96356-56-8
Boc-Tyr-Arg(NO₂)-Lys(Z)-Asp(OBzl)-D-Val-OBu^t

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; 1.) -15 deg C to room temp., 2.) 2d, room temp.;
DOI:10.1002/jlac.198619860507

Reference yield:

: Z-D-Val-OBu^t*TosOH

: 96356-56-8
Boc-Tyr-Arg(NO₂)-Lys(Z)-Asp(OBzl)-D-Val-OBu^t

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / hydrogen / 5percent Pd/C / methanol / 8 h

2: 83 percent / PPA,NMM / CH₂Cl₂ / 1.) -15 deg C to room temp., 2.) 2d, room temp.

3: 95 percent / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 31 percent / NMM,PPA / CH₂Cl₂ / 1.) -15 deg C to room temp., 2.) 2d, room temp.

With 4-methyl-morpholine; PPA,NMM; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/jlac.198619860507

Reference yield:

: 2528-15-6,6070-59-3,13211-31-9,21691-52-1
D-valine t-butyl ester

: 96356-56-8
Boc-Tyr-Arg(NO₂)-Lys(Z)-Asp(OBzl)-D-Val-OBu^t

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / PPA,NMM / CH₂Cl₂ / 1.) -15 deg C to room temp., 2.) 2d, room temp.

2: 95 percent / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 31 percent / NMM,PPA / CH₂Cl₂ / 1.) -15 deg C to room temp., 2.) 2d, room temp.

With 4-methyl-morpholine; PPA,NMM; In dichloromethane;
DOI:10.1002/jlac.198619860507