Technology Process of 5,7,14,16-Tetrakis(mercaptomethyl)-2,11-bis(p-tolylsulfonyl)-2,11-diaza<3.3>metacyclophan
There total 8 articles about 5,7,14,16-Tetrakis(mercaptomethyl)-2,11-bis(p-tolylsulfonyl)-2,11-diaza<3.3>metacyclophan which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: thionyl chloride, DMF / Heating
2: Heating
3: 70 percent / NBS, AIBN / CH2Cl2 / 3 h / Heating; Irradiation
4: 26 percent / dimethylformamide / 4 h / 80 °C
5: 1) LiAlH4 / 1) THF, room temperature, 1 h, then reflux, 2h, 2) reflux, 2 h
6: 75 percent / HBr / acetic acid / 6 h / Ambient temperature
7: 1) thiourea, 2) 10percent aq. NaOH / 1) DMSO, room temperature, 1 d, 2) 0-5 deg C, 1 h
With
sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; thionyl chloride; 2,2'-azobis(isobutyronitrile); hydrogen bromide; thiourea; N,N-dimethyl-formamide;
In
dichloromethane; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1) KOH, H2O, 2) KMnO4 / 1) reflux, 4-5 h, 12 h
2: thionyl chloride, DMF / Heating
3: Heating
4: 70 percent / NBS, AIBN / CH2Cl2 / 3 h / Heating; Irradiation
5: 26 percent / dimethylformamide / 4 h / 80 °C
6: 1) LiAlH4 / 1) THF, room temperature, 1 h, then reflux, 2h, 2) reflux, 2 h
7: 75 percent / HBr / acetic acid / 6 h / Ambient temperature
8: 1) thiourea, 2) 10percent aq. NaOH / 1) DMSO, room temperature, 1 d, 2) 0-5 deg C, 1 h
With
potassium hydroxide; sodium hydroxide; potassium permanganate; N-Bromosuccinimide; lithium aluminium tetrahydride; thionyl chloride; 2,2'-azobis(isobutyronitrile); water; hydrogen bromide; thiourea; N,N-dimethyl-formamide;
In
dichloromethane; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Heating
2: 70 percent / NBS, AIBN / CH2Cl2 / 3 h / Heating; Irradiation
3: 26 percent / dimethylformamide / 4 h / 80 °C
4: 1) LiAlH4 / 1) THF, room temperature, 1 h, then reflux, 2h, 2) reflux, 2 h
5: 75 percent / HBr / acetic acid / 6 h / Ambient temperature
6: 1) thiourea, 2) 10percent aq. NaOH / 1) DMSO, room temperature, 1 d, 2) 0-5 deg C, 1 h
With
sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); hydrogen bromide; thiourea;
In
dichloromethane; acetic acid; N,N-dimethyl-formamide;
