5-[[3-(Dimethylamino)-4-methoxyphenyl]methyl]pyrimidine-2,4-diamine

Base Information

Chemical Name:5-[[3-(Dimethylamino)-4-methoxyphenyl]methyl]pyrimidine-2,4-diamine
CAS No.:85544-46-3
Molecular Formula:C₁₄H₁₉N₅O
Molecular Weight:273.338
Hs Code.:
DSSTox Substance ID:DTXSID10877588
Nikkaji Number:J1.589.352D
Wikidata:Q82859421

Synonyms:85544-46-3;DTXSID10877588;2,4-PYRIMIDINEDIAMINE, 5-[[3-(DIMETHYLAMINO)-4-M

Suppliers and Price of 5-[[3-(Dimethylamino)-4-methoxyphenyl]methyl]pyrimidine-2,4-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[[3-(Dimethylamino)-4-methoxyphenyl]methyl]pyrimidine-2,4-diamine

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:273.15896025
Heavy Atom Count:20
Complexity:301

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)C1=C(C=CC(=C1)CC2=CN=C(N=C2N)N)OC

Technology Process of 5-[[3-(Dimethylamino)-4-methoxyphenyl]methyl]pyrimidine-2,4-diamine

There total 4 articles about 5-[[3-(Dimethylamino)-4-methoxyphenyl]methyl]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 344332-16-7
methyl 3-N,N-dimethylamino-4-methoxybenzoate

: 85544-46-3
5-(3-Dimethylamino-4-methoxy-benzyl)-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium amide / dimethylsulfoxide; toluene / 1 h / 60 °C

2: NaBH₄ / ethanol; H₂O / 1 h / Ambient temperature

3: t-BuOK / dimethylsulfoxide / 2 h / 50 °C

4: EtONa / ethanol / 20 h / Heating

With sodium tetrahydroborate; potassium tert-butylate; sodium ethanolate; sodium amide; In ethanol; water; dimethyl sulfoxide; toluene;

Reference yield:

: 344347-44-0
1-(3-Dimethylamino-4-methoxy-phenyl)-2-methanesulfonyl-ethanone

: 85544-46-3
5-(3-Dimethylamino-4-methoxy-benzyl)-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / ethanol; H₂O / 1 h / Ambient temperature

2: t-BuOK / dimethylsulfoxide / 2 h / 50 °C

3: EtONa / ethanol / 20 h / Heating

With sodium tetrahydroborate; potassium tert-butylate; sodium ethanolate; In ethanol; water; dimethyl sulfoxide;

Reference yield:

: 344347-43-9
1-(3-Dimethylamino-4-methoxy-phenyl)-2-methanesulfonyl-ethanol

: 85544-46-3
5-(3-Dimethylamino-4-methoxy-benzyl)-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: t-BuOK / dimethylsulfoxide / 2 h / 50 °C

2: EtONa / ethanol / 20 h / Heating

With potassium tert-butylate; sodium ethanolate; In ethanol; dimethyl sulfoxide;