6-(2-methoxybenzoyl)-2-acetyl-5,8-dimethoxytetralin

Base Information

Chemical Name:6-(2-methoxybenzoyl)-2-acetyl-5,8-dimethoxytetralin
CAS No.:82891-44-9
Molecular Formula:C₂₂H₂₄O₅
Molecular Weight:368.43
Hs Code.:

Synonyms:

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Chemical Property of 6-(2-methoxybenzoyl)-2-acetyl-5,8-dimethoxytetralin

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Technology Process of 6-(2-methoxybenzoyl)-2-acetyl-5,8-dimethoxytetralin

There total 8 articles about 6-(2-methoxybenzoyl)-2-acetyl-5,8-dimethoxytetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82891-41-6
3,3-dicarbethoxy-5,8-dimethoxy-1-tetralone

: 82891-44-9
6-(2-methoxybenzoyl)-2-acetyl-5,8-dimethoxytetralin

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂, HCl / 5percent Pd/C / aq. ethanol / 760 Torr

2: 96 percent / aq. KOH / ethanol / 3 h / 90 °C

3: 96 percent / acetic acid, piperidine / 1 h / 120 - 125 °C

4: 98 percent / tetrahydrofuran; diethyl ether / 6 h / -10 °C

5: SnCl₄ / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, 12 h

With piperidine; hydrogenchloride; potassium hydroxide; hydrogen; tin(IV) chloride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo00143a026

Reference yield:

: 82891-40-5
4-(2,5-dimethoxyphenyl)-3,3-dicarbethoxybutanoic acid

: 82891-44-9
6-(2-methoxybenzoyl)-2-acetyl-5,8-dimethoxytetralin

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / (CF₃CO)2O, CF₃COOH / 14 h / Ambient temperature

2: 100 percent / H₂, HCl / 5percent Pd/C / aq. ethanol / 760 Torr

3: 96 percent / aq. KOH / ethanol / 3 h / 90 °C

4: 96 percent / acetic acid, piperidine / 1 h / 120 - 125 °C

5: 98 percent / tetrahydrofuran; diethyl ether / 6 h / -10 °C

6: SnCl₄ / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, 12 h

With piperidine; hydrogenchloride; potassium hydroxide; hydrogen; tin(IV) chloride; acetic acid; trifluoroacetic acid; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo00143a026

Reference yield:

: 70767-97-4
4-(2,5-Dimethoxy-phenyl)-3,3-bis-ethoxycarbonyl-butyric acid methyl ester

: 82891-44-9
6-(2-methoxybenzoyl)-2-acetyl-5,8-dimethoxytetralin

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / aq. KOH / tetrahydrofuran; methanol / 36 h / Ambient temperature

2: 97 percent / (CF₃CO)2O, CF₃COOH / 14 h / Ambient temperature

3: 100 percent / H₂, HCl / 5percent Pd/C / aq. ethanol / 760 Torr

4: 96 percent / aq. KOH / ethanol / 3 h / 90 °C

5: 96 percent / acetic acid, piperidine / 1 h / 120 - 125 °C

6: 98 percent / tetrahydrofuran; diethyl ether / 6 h / -10 °C

7: SnCl₄ / CH₂Cl₂ / 1.) 0 deg C, 2.) RT, 12 h

With piperidine; hydrogenchloride; potassium hydroxide; hydrogen; tin(IV) chloride; acetic acid; trifluoroacetic acid; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo00143a026