1,1'-Biphenyl, 2,2'-bis(methoxymethoxy)-

Base Information

• Chemical Name: 1,1'-Biphenyl, 2,2'-bis(methoxymethoxy)-
• CAS No.: 121169-22-0
• Molecular Formula: C16H18O4
• Molecular Weight: 274.317
• DSSTox Substance ID: DTXSID50466995
• Nikkaji Number: J2.196.689D
• Wikidata: Q82293725
• Mol file: 121169-22-0.mol

Synonyms:1,1'-Biphenyl, 2,2'-bis(methoxymethoxy)-;121169-22-0;2,2'-Bis-(methoxymethoxy)bibenzene;SCHEMBL6048623;DTXSID50466995;UQRJDQWLBHCSLR-UHFFFAOYSA-N

Chemical Property of 1,1'-Biphenyl, 2,2'-bis(methoxymethoxy)-

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 274.12050905
• Heavy Atom Count: 20
• Complexity: 233

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=CC=CC=C1C2=CC=CC=C2OCOC

Technology Process of 1,1'-Biphenyl, 2,2'-bis(methoxymethoxy)-

There total 6 articles about 1,1'-Biphenyl, 2,2'-bis(methoxymethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(2-methoxymethoxy)phenylzinc chloride + methyl (E)-2,3-dibromo-2-octenoate (176246-52-9) → methyl 2-octynoate (111-12-6,53073-28-2) + 2,2'-bis(methoxymethoxy)-1,1'-biphenyl (121169-22-0) + methyl (E)-2-bromo-3-<(2-methoxymethoxy)phenyl>-2-octenoate + (Z)-2,3-Bis-(2-methoxymethoxy-phenyl)-oct-2-enoic acid methyl ester

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 71h;

DOI:10.1016/S0040-4020(96)00071-3

Reference yield: 24.0%

Dibromo-2,3-crotonsaeureethylester (28113-30-6) + (2-methoxymethoxy)phenylzinc chloride → Ethyl 2-butynoate (4341-76-8) + 2,2'-bis(methoxymethoxy)-1,1'-biphenyl (121169-22-0) + ethyl (E)-2-bromo-3-<(2-methoxymethoxy)phenyl>-2-butenoate + (Z)-2,3-Bis-(2-methoxymethoxy-phenyl)-but-2-enoic acid ethyl ester

Guidance literature:

With palladium diacetate; triphenyl-arsane; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1016/S0040-4020(96)00071-3

Reference yield:

ethyl (E)-2,3-dibromo-2-phenylpropenoate (176246-53-0,22711-52-0) + (2-methoxymethoxy)phenylzinc chloride → 2,2'-bis(methoxymethoxy)-1,1'-biphenyl (121169-22-0) + (Z)-2,3-Bis-(2-methoxymethoxy-phenyl)-3-phenyl-acrylic acid ethyl ester + (E)-2-Bromo-3-(2-methoxymethoxy-phenyl)-3-phenyl-acrylic acid ethyl ester + (Z)-2-Bromo-3-(2-methoxymethoxy-phenyl)-3-phenyl-acrylic acid ethyl ester

Guidance literature:

With palladium diacetate; triphenyl-arsane; In tetrahydrofuran; at 20 ℃; for 72h; Further byproducts given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(96)00071-3

upstream raw materials:

O-methoxymethylphenol

acetic anhydride

Dibromo-2,3-crotonsaeureethylester

ethyl (E)-2,3-dibromo-2-phenylpropenoate