tert-butyl-N-((R)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-7H-inden-1-yl)heptyl)sulfamoylcarbamate

Base Information

• Chemical Name: tert-butyl-N-((R)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-7H-inden-1-yl)heptyl)sulfamoylcarbamate
• CAS No.: 1188932-02-6
• Molecular Formula: C₄₂H₈₀N₂O₆SSi₂
• Molecular Weight: 797.344
• Mol file: 1188932-02-6.mol

Synonyms:

Chemical Property of tert-butyl-N-((R)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-7H-inden-1-yl)heptyl)sulfamoylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-N-((R)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-7H-inden-1-yl)heptyl)sulfamoylcarbamate

There total 2 articles about tert-butyl-N-((R)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-7H-inden-1-yl)heptyl)sulfamoylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ tert-butyl-N-((R)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-7H-inden-1-yl)heptyl)sulfamoylcarbamate (1188932-02-6)

Guidance literature:

Reference yield:

(R)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)heptan-1-amine (1188931-92-1) + (tert-butoxycarbonyl)-((4-(dimethyliminio)pyridin-1(4H)-yl)sulfonyl)amide (352275-00-4,872496-91-8) → tert-butyl-N-((R)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-7H-inden-1-yl)heptyl)sulfamoylcarbamate (1188932-02-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2010.03.078

Reference yield:

tert-butyl-N-((R)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-7H-inden-1-yl)heptyl)sulfamoylcarbamate (1188932-02-6) → N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycycloheptylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexyl)methanesulfamide (1188931-76-1)

Guidance literature:

With hydrogen fluoride; In dichloromethane; acetonitrile; at 20 ℃;

DOI:10.1016/j.bmc.2010.03.078

upstream raw materials:

(R)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)heptan-1-amine

(tert-butoxycarbonyl)-((4-(dimethyliminio)pyridin-1(4H)-yl)sulfonyl)amide

Downstream raw materials:

N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycycloheptylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexyl)methanesulfamide