Technology Process of (2R,4aR,5R)-5-Benzyloxy-2-methyl-1-oxo-2,4a,5,6-tetrahydro-1H-1λ4-[1,2]thiazino[2,3-c][1,3]oxazin-8-one
There total 5 articles about (2R,4aR,5R)-5-Benzyloxy-2-methyl-1-oxo-2,4a,5,6-tetrahydro-1H-1λ4-[1,2]thiazino[2,3-c][1,3]oxazin-8-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
thionyl chloride;
In
pyridine; toluene;
0 deg C, 2 h (adding), up to RT, then RT, 14 h;
DOI:10.1016/S0040-4020(01)96517-2
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) 0.88 M n-butyllithium / 1.) THF, hexane, -78 deg C, 5 min (adding), then l5 min, 2.) -78 deg C, 1 h
2: 1.) potassium hydride, 2.) 18-crown-6, 3.) NaI / 1.) THF, -15 deg C (adding), then 20 min, 2.) up to 0 deg C, 45 min, 3.) up to RT, then 12 h
3: tetrahydrofuran; H2O; acetic acid / 20 h
4: 75 percent / trifluoroacetic acid / benzene / Ambient temperature; 2.5 h adding, then 12 h
5: 57 percent / thionyl chloride / toluene; pyridine / 0 deg C, 2 h (adding), up to RT, then RT, 14 h
With
n-butyllithium; thionyl chloride; 18-crown-6 ether; potassium hydride; trifluoroacetic acid; sodium iodide;
In
tetrahydrofuran; pyridine; water; acetic acid; toluene; benzene;
DOI:10.1016/S0040-4020(01)96517-2
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) potassium hydride, 2.) 18-crown-6, 3.) NaI / 1.) THF, -15 deg C (adding), then 20 min, 2.) up to 0 deg C, 45 min, 3.) up to RT, then 12 h
2: tetrahydrofuran; H2O; acetic acid / 20 h
3: 75 percent / trifluoroacetic acid / benzene / Ambient temperature; 2.5 h adding, then 12 h
4: 57 percent / thionyl chloride / toluene; pyridine / 0 deg C, 2 h (adding), up to RT, then RT, 14 h
With
thionyl chloride; 18-crown-6 ether; potassium hydride; trifluoroacetic acid; sodium iodide;
In
tetrahydrofuran; pyridine; water; acetic acid; toluene; benzene;
DOI:10.1016/S0040-4020(01)96517-2
