Technology Process of 3-[1-(4-methylphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid tromethamine salt
There total 7 articles about 3-[1-(4-methylphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid tromethamine salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: titanium tetrachloride / dichloromethane / 3 h / 20 °C
2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 20 °C
3.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 5 h / 120 °C / Sealed tube
4.1: palladium on activated charcoal; hydrogen / methanol / 20 °C
5.1: johnphos; potassium phosphate; palladium diacetate / 1,2-dimethoxyethane / 110 °C / Sealed tube
6.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating
6.2: pH 1
7.1: water; tetrahydrofuran / 20 °C
With
potassium phosphate; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; palladium diacetate; titanium tetrachloride; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; johnphos;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; toluene;
3.1: |Heck Reaction;
DOI:10.1021/jm500494y
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 20 °C
2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 5 h / 120 °C / Sealed tube
3.1: palladium on activated charcoal; hydrogen / methanol / 20 °C
4.1: johnphos; potassium phosphate; palladium diacetate / 1,2-dimethoxyethane / 110 °C / Sealed tube
5.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating
5.2: pH 1
6.1: water; tetrahydrofuran / 20 °C
With
potassium phosphate; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; johnphos;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; water; toluene;
2.1: |Heck Reaction;
DOI:10.1021/jm500494y
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 5 h / 120 °C / Sealed tube
2.1: palladium on activated charcoal; hydrogen / methanol / 20 °C
3.1: johnphos; potassium phosphate; palladium diacetate / 1,2-dimethoxyethane / 110 °C / Sealed tube
4.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating
4.2: pH 1
5.1: water; tetrahydrofuran / 20 °C
With
potassium phosphate; palladium on activated charcoal; hydrogen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; johnphos;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; toluene;
1.1: |Heck Reaction;
DOI:10.1021/jm500494y
