N,N-dimethyl-2-methoxy-3-(2-methoxy-phenoxy)-3-phenyl-propanamine hydrochloride

Base Information

Chemical Name:N,N-dimethyl-2-methoxy-3-(2-methoxy-phenoxy)-3-phenyl-propanamine hydrochloride
CAS No.:93851-82-2
Molecular Formula:C₁₉H₂₅NO₃*ClH
Molecular Weight:351.873
Hs Code.:

Synonyms:

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Chemical Property of N,N-dimethyl-2-methoxy-3-(2-methoxy-phenoxy)-3-phenyl-propanamine hydrochloride

Chemical Property:

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Technology Process of N,N-dimethyl-2-methoxy-3-(2-methoxy-phenoxy)-3-phenyl-propanamine hydrochloride

There total 14 articles about N,N-dimethyl-2-methoxy-3-(2-methoxy-phenoxy)-3-phenyl-propanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: N-ethoxycarbonyl-N-methyl-2-methoxy-3-(2-methoxy-phenoxy)-3-phenylpropanamine

: 93851-82-2,93853-22-6
N,N-dimethyl-2-methoxy-3-(2-methoxy-phenoxy)-3-phenyl-propanamine hydrochloride

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 16h; Heating;

Reference yield:

: 10606-73-2,99531-04-1,116836-53-4,4773-33-5
ethyl 2-chloro-2-phenylacetate

: 93851-82-2,93853-22-6
N,N-dimethyl-2-methoxy-3-(2-methoxy-phenoxy)-3-phenyl-propanamine hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: SOCl₂ / 16 h / Ambient temperature

4: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

5: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

6: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

7: 95 percent / NaOH / CHCl₃

8: 100 percent / NaH / dimethylformamide / 2 h / 5 °C

9: 66 percent / LiAlH₄ / diethyl ether / 16 h / Heating

With potassium cyanide; sodium metabisulfite; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; sodium hydride; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; methanol; diethyl ether; chloroform; diethylene glycol dimethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 90-05-1
2-methoxy-phenol

: 93851-82-2,93853-22-6
N,N-dimethyl-2-methoxy-3-(2-methoxy-phenoxy)-3-phenyl-propanamine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: 1.) carbonyl-diimidazole; 2.) nitromethane Na salt / 1.) THF, reflux, 1 h; 2.) THF, reflux, 16 h

4: 72 percent / H₂, H₂SO₄ / PtO₂ / acetic acid / 0.67 h / 1900 Torr

5: 95 percent / NaOH / CHCl₃

6: 100 percent / NaH / dimethylformamide / 2 h / 5 °C

7: 66 percent / LiAlH₄ / diethyl ether / 16 h / Heating

With potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; Carbonyldiimidazole; sulfuric acid; hydrogen; sodium nitromethane; sodium hydride; platinum(IV) oxide; In methanol; diethyl ether; chloroform; acetic acid; N,N-dimethyl-formamide;