(1S)-(1α,2α,3β,4α,5β,6β)-6-<(methyl)amino>-1,2-O-isopropylidene-4-O-<(2-methoxyethoxy)methyl>-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol

Base Information

Chemical Name:(1S)-(1α,2α,3β,4α,5β,6β)-6-<(methyl)amino>-1,2-O-isopropylidene-4-O-<(2-methoxyethoxy)methyl>-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol
CAS No.:104619-44-5
Molecular Formula:C₃₇H₄₇N₃O₇
Molecular Weight:645.796
Hs Code.:

(1S)-(1α,2α,3β,4α,5β,6β)-6-<<N-(Diphenylmethylen)glycyl>(methyl)amino>-1,2-O-isopropylidene-4-O-<(2-methoxyethoxy)methyl>-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol

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Chemical Property of (1S)-(1α,2α,3β,4α,5β,6β)-6-<(methyl)amino>-1,2-O-isopropylidene-4-O-<(2-methoxyethoxy)methyl>-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol

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Technology Process of (1S)-(1α,2α,3β,4α,5β,6β)-6-<(methyl)amino>-1,2-O-isopropylidene-4-O-<(2-methoxyethoxy)methyl>-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol

There total 5 articles about (1S)-(1α,2α,3β,4α,5β,6β)-6-<(methyl)amino>-1,2-O-isopropylidene-4-O-<(2-methoxyethoxy)methyl>-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14683-47-7
N-(diphenylmethyl)methylamine

: 104619-32-1
(3aS,4R,5R,5aR,8aR,8bR)-5-(2-Methoxy-ethoxymethoxy)-2,2,8-trimethyl-4-((R)-1-phenyl-ethylamino)-hexahydro-[1,3]dioxolo[4',5':3,4]benzo[2,1-d]oxazol-7-one

: 104619-44-5
2-(Benzhydrylidene-amino)-N-[(3aR,4S,5R,6R,7R,7aS)-5-hydroxy-6-(2-methoxy-ethoxymethoxy)-2,2-dimethyl-7-((R)-1-phenyl-ethylamino)-hexahydro-benzo[1,3]dioxol-4-yl]-N-methyl-acetamide

Guidance literature:: With lithium; In diethyl ether; at -20 ℃; for 0.166667h;

Reference yield:

: 104713-72-6
Methyl-carbamic acid (3aS,4S,5R,6S,7S,7aS)-4,7-dihydroxy-3-methyl-2-oxo-6-((R)-1-phenyl-ethylamino)-octahydro-benzooxazol-5-yl ester

: 104619-44-5
(1S)-(1α,2α,3β,4α,5β,6β)-6-<(methyl)amino>-1,2-O-isopropylidene-4-O-<(2-methoxyethoxy)methyl>-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / p-TsOH / dimethylformamide / 2 h / 80 °C

2: 1.) NaH / 1.) glyme, 20 deg C, 15 min; 2.) 1 h

3: 1.) i-Pr₂NH, BuLi / 1.) hexane, THF, -78 deg C, 20 min; 2.) 10 min

With n-butyllithium; sodium hydride; toluene-4-sulfonic acid; diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1002/jlac.198619861201

Reference yield:

: 88643-00-9
(-)-(1S)-(1α,2α,3β,4α,5β,6β)-5-O,6-N-Carbonyl-1,2-O-isopropylidene-6-(methylamino)-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol

: 104619-44-5
(1S)-(1α,2α,3β,4α,5β,6β)-6-<(methyl)amino>-1,2-O-isopropylidene-4-O-<(2-methoxyethoxy)methyl>-3-<(R)-(1-phenylethyl)amino>-1,2,4,5-cyclohexanetetrol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) glyme, 20 deg C, 15 min; 2.) 1 h

2: 1.) i-Pr₂NH, BuLi / 1.) hexane, THF, -78 deg C, 20 min; 2.) 10 min

With n-butyllithium; sodium hydride; diisopropylamine;
DOI:10.1002/jlac.198619861201