(S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester
CAS No.:145763-51-5
Molecular Formula:C₄₅H₅₃N₅O₁₁S
Molecular Weight:872.009
Hs Code.:

(S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

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Chemical Property of (S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

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Technology Process of (S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

There total 13 articles about (S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 145763-41-3
N-benzyloxycarbonyl-O-tosyl-(Z)dehydrotyrosyl-(R)alanyl-glycyl-(S)phenylalanyl-(S)leucine methyl ester

: 145763-51-5,145763-52-6
(S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: With [Rh((R,R)-DIPAMP)(COD)]BF₄; hydrogen; In methanol; for 48h; under 7500.6 Torr;
DOI:10.1016/S0957-4166(00)82083-2

Reference yield:

: 3850-45-1
Cbz-L-Phe-L-Leu-OMe

: 145763-51-5,145763-52-6
(S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / H₂, 2 N aq. HCl / 10percent Pd/C / methanol / 760 Torr

2: 65 percent / N-methyl morpholine, N,N-dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 18 h / Ambient temperature

3: 98 percent / H₂ / 10percent Pd/C / methanol / 760 Torr

4: 55 percent / N-methyl morpholine, N,N-dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 18 h / Ambient temperature

5: 90 percent / H₂, ⁺BF₄^- / methanol / 48 h / 7500.6 Torr

With 4-methyl-morpholine; hydrogenchloride; [Rh((R,R)-DIPAMP)(COD)]BF₄; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0957-4166(00)82083-2

Reference yield:

: 34286-66-3
N-benzyloxycarbonyl-(R)alanyl-glycine

: 145763-51-5,145763-52-6
(S)-2-{(S)-2-[2-((R)-2-{2-Benzyloxycarbonylamino-3-[4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / N-methyl morpholine, N,N-dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 18 h / Ambient temperature

2: 98 percent / H₂ / 10percent Pd/C / methanol / 760 Torr

3: 55 percent / N-methyl morpholine, N,N-dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 18 h / Ambient temperature

4: 90 percent / H₂, ⁺BF₄^- / methanol / 48 h / 7500.6 Torr

With 4-methyl-morpholine; [Rh((R,R)-DIPAMP)(COD)]BF₄; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0957-4166(00)82083-2