C₄₄H₆₀O₈S₂Si

Base Information

• Chemical Name: C₄₄H₆₀O₈S₂Si
• CAS No.: 344315-39-5
• Molecular Formula: C₄₄H₆₀O₈S₂Si
• Molecular Weight: 809.173
• Mol file: 344315-39-5.mol

Synonyms:

Chemical Property of C₄₄H₆₀O₈S₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₆₀O₈S₂Si

There total 20 articles about C₄₄H₆₀O₈S₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C44H61IO7S2Si → C44H60O8S2Si (344315-39-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

DOI:10.1016/S0040-4039(01)00286-6

Reference yield:

(2S,3S,4R,4aR,6R,7S,8aR)-2-Allyl-3,4-bis-benzyloxy-6-(3,3-dibromo-allyl)-7-(1-ethoxy-ethoxy)-octahydro-pyrano[3,2-b]pyran → C44H60O8S2Si (344315-39-5)

Guidance literature:

Multi-step reaction with 20 steps

1.1: n-BuLi / tetrahydrofuran

2.1: Amberlyst-15E / methanol

3.1: Co₂(CO)8; BF₃*OEt₂ / CH₂Cl₂

3.2: propargyl alcohol / 1,2-dichloro-ethane / 60 °C

4.1: Jones' reagent / acetone

4.2: 88 percent / PdCl₂; CuCl / dimethylformamide; H₂O

5.1: 86 percent / I(collidine)2PF₆- / CH₂Cl₂

6.1: 90 percent / BF₃*OEt₂ / CH₂Cl₂

7.1: DIBAL-H / CH₂Cl₂

8.1: DBU / tetrahydrofuran

9.1: 81 percent / K₂CO₃ / methanol

10.1: 90 percent / BF₃*OEt₂ / CH₂Cl₂

11.1: p-nitro benzoic acid; DEAD; PPh₃ / toluene

11.2: 94 percent / K₂CO₃ / methanol

12.1: PPTS / CH₂Cl₂

13.1: n-BuLi / tetrahydrofuran

14.1: Amberlyst-15E / methanol

15.1: Jones' reagent / acetone

16.1: I(collidine)2PF₆ / CH₂Cl₂

17.1: BF₃*OEt₂ / CH₂Cl₂

18.1: DIBAL-H / CH₂Cl₂

19.1: DBU / tetrahydrofuran

With n-butyllithium; jones' reagent; dicobalt octacarbonyl; Amberlyst-15E; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; 4.1: Wacker oxidation / 11.1: modified Mitsunobu inversion;

DOI:10.1016/S0040-4039(01)00286-6

Reference yield:

(2S,3S,4R,4aR,5aR,8R,9R,10aS,11aR)-3,4-Bis-benzyloxy-2-(2-methyl-[1,3]dithian-2-ylmethyl)-9-prop-2-ynyl-2,3,4,4a,5a,8,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-8-ol (344315-36-2) → C44H60O8S2Si (344315-39-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: p-nitro benzoic acid; DEAD; PPh₃ / toluene

1.2: 94 percent / K₂CO₃ / methanol

2.1: PPTS / CH₂Cl₂

3.1: n-BuLi / tetrahydrofuran

4.1: Amberlyst-15E / methanol

5.1: Jones' reagent / acetone

6.1: I(collidine)2PF₆ / CH₂Cl₂

7.1: BF₃*OEt₂ / CH₂Cl₂

8.1: DIBAL-H / CH₂Cl₂

9.1: DBU / tetrahydrofuran

With n-butyllithium; jones' reagent; Amberlyst-15E; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; 1.1: modified Mitsunobu inversion;

DOI:10.1016/S0040-4039(01)00286-6

upstream raw materials:

(2S,3S,4R,4aR,5aR,8S,9R,10aS,11aR)-3,4-Bis-benzyloxy-2-(2-methyl-[1,3]dithian-2-ylmethyl)-9-prop-2-ynyl-2,3,4,4a,5a,8,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-8-ol

(2S,3S,4R,4aR,5aR,8R,9R,10aS,11aR)-3,4-Bis-benzyloxy-2-(2-methyl-[1,3]dithian-2-ylmethyl)-9-prop-2-ynyl-2,3,4,4a,5a,8,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-8-ol

2-((2S,3S,4R,4aR,5aR,9R,10aS,11aR)-2-Allyl-3,4-bis-benzyloxy-7-triethylsilanyl-2,3,4,4a,5a,6,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-9-yl)-ethanol

(2S,3S,4R,4aR,5aR,8S,9R,10aS,11aR)-3,4-Bis-benzyloxy-8-(1-ethoxy-ethoxy)-2-(2-methyl-[1,3]dithian-2-ylmethyl)-9-prop-2-ynyl-2,3,4,4a,5a,8,9,10a,11,11a-decahydro-1,5,10-trioxa-cyclohepta[b]naphthalene

Downstream raw materials:

C₄₁H₄₈O₇S₂

C₅₀H₆₈O₇S₂Si

C₅₆H₈₂O₇S₂Si₂