(2S,3S,3aR,9aR)-3-(2-Azido-ethoxy)-2-(2,4-difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

Base Information

Chemical Name:(2S,3S,3aR,9aR)-3-(2-Azido-ethoxy)-2-(2,4-difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene
CAS No.:689222-02-4
Molecular Formula:C₂₅H₄₁F₂N₃O₅Si₂
Molecular Weight:557.785
Hs Code.:

(2S,3S,3aR,9aR)-3-(2-Azido-ethoxy)-2-(2,4-difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

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Chemical Property of (2S,3S,3aR,9aR)-3-(2-Azido-ethoxy)-2-(2,4-difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

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Technology Process of (2S,3S,3aR,9aR)-3-(2-Azido-ethoxy)-2-(2,4-difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

There total 6 articles about (2S,3S,3aR,9aR)-3-(2-Azido-ethoxy)-2-(2,4-difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 689221-98-5
2-[(2S,3S,3aR,9aR)-2-(2,4-Difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy]-ethanol

: 689222-02-4
(2S,3S,3aR,9aR)-3-(2-Azido-ethoxy)-2-(2,4-difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

Guidance literature:: With sodium azide; triphenylphosphine; diethylazodicarboxylate;
DOI:10.1081/NCN-120022962

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 689222-02-4
(2S,3S,3aR,9aR)-3-(2-Azido-ethoxy)-2-(2,4-difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

Guidance literature:: Multi-step reaction with 5 steps

1: 54 percent / pyridine

2: 76 percent / NaH / tetrahydrofuran

3: 57 percent / LiBH₄ / tetrahydrofuran; methanol

4: 59 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂

5: NaN₃ / dimethylformamide

With pyridine; dmap; lithium borohydride; sodium azide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120022962

Reference yield:

: 263701-23-1
1'-deoxy-β-1'-(2,4-difluorophenyl)-D-ribofuranose

: 689222-02-4
(2S,3S,3aR,9aR)-3-(2-Azido-ethoxy)-2-(2,4-difluoro-phenyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacyclooctene

Guidance literature:: Multi-step reaction with 5 steps

1: 54 percent / pyridine

2: 76 percent / NaH / tetrahydrofuran

3: 57 percent / LiBH₄ / tetrahydrofuran; methanol

4: 59 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂

5: NaN₃ / dimethylformamide

With pyridine; dmap; lithium borohydride; sodium azide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120022962