Technology Process of (S)-5-Dimethylamino-3-(1-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperidin-4-yl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one
There total 11 articles about (S)-5-Dimethylamino-3-(1-{2-hydroxy-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperidin-4-yl)-1-methyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 0 - 20 °C
2: dichloromethane; methanol / 18 h / 20 °C
3: hydrogen / 1 % platinum on carbon / ethyl acetate / 45 °C / 2327.23 Torr / Inert atmosphere
4: 4 h / 0 - 20 °C
5: potassium carbonate / N,N-dimethyl-formamide / 1 h / Reflux
6: potassium hydroxide; water / ethanol / 10.5 h / 84 - 85 °C / Industry scale
7: ethanol / 6 h / Reflux
With
water; hydrogen; potassium carbonate; potassium hydroxide;
1 % platinum on carbon;
In
methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 0 - 20 °C
2: dichloromethane; methanol / 18 h / 20 °C
3: hydrogen / 1 % platinum on carbon / ethyl acetate / 45 °C / 2327.23 Torr / Inert atmosphere
4: 4 h / 0 - 20 °C
5: potassium carbonate / N,N-dimethyl-formamide / 1 h / Reflux
6: potassium hydroxide; water / ethanol / 10.5 h / 84 - 85 °C / Industry scale
7: ethanol / 6 h / Reflux
With
water; hydrogen; potassium carbonate; potassium hydroxide;
1 % platinum on carbon;
In
methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-methylpiperidin; toluene-4-sulfonic acid / toluene / Reflux
1.2: -20 - 20 °C
2.1: hydrazine hydrochloride; sodium hydroxide / ethanol; water / 1.33 h
2.2: 6.75 h / 20 °C / Reflux
3.1: caesium carbonate / N,N-dimethyl-formamide / 8 - 20 °C / Inert atmosphere
4.1: ethanol / 6 h / Reflux
With
4-methylpiperidin; hydrazine hydrochloride; caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
