Technology Process of Benzenesulfonic acid 8-methoxy-5,10-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a]azepin-7-yl ester
There total 8 articles about Benzenesulfonic acid 8-methoxy-5,10-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a]azepin-7-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 87 percent / Ca(OH)2 / H2O / 45 h / Ambient temperature
2: 93 percent / KOH / methanol / 30 h / 40 - 45 °C
3: 96 percent / K2CO3 / dimethylformamide / 20 h / Ambient temperature
4: 98 percent / conc. HCl / H2O; acetic acid / 4 h / Heating
5: 77 percent / ethyl carbamate / 65 h / 150 - 160 °C
6: 1.) KH, 2.) tetrabutylammonium bromide / 1.) THF, 2 h, 2.) benzene, reflux, 22 h
7: acetonitrile / 0.5 h / Irradiation
With
hydrogenchloride; calcium hydroxide; potassium hydroxide; tetrabutylammomium bromide; potassium hydride; potassium carbonate; urethane;
In
methanol; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00285a022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) KH, 2.) tetrabutylammonium bromide / 1.) THF, 2 h, 2.) benzene, reflux, 22 h
2: acetonitrile / 0.5 h / Irradiation
With
tetrabutylammomium bromide; potassium hydride;
In
acetonitrile;
DOI:10.1021/jo00285a022
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 77 percent / ethyl carbamate / 65 h / 150 - 160 °C
2: 1.) KH, 2.) tetrabutylammonium bromide / 1.) THF, 2 h, 2.) benzene, reflux, 22 h
3: acetonitrile / 0.5 h / Irradiation
With
tetrabutylammomium bromide; potassium hydride; urethane;
In
acetonitrile;
DOI:10.1021/jo00285a022
