(3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

Base Information

Chemical Name:(3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester
CAS No.:119750-98-0
Molecular Formula:C₂₅H₂₂N₆O₆S
Molecular Weight:534.552
Hs Code.:

(3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

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Chemical Property of (3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

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Technology Process of (3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

There total 7 articles about (3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119750-97-9
N⁶-benzoyl-2',3'-isopropylidene-5'-carboxylic acid-5'-deoxy-adenosine

: 1121-31-9
2-mercaptopyridine N-oxide

: 119750-98-0
(3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1039/c39890001000

Reference yield:

: 3696-28-4
2,2'-dipyridyl disulfide bis-N-oxide

: 119750-97-9
N⁶-benzoyl-2',3'-isopropylidene-5'-carboxylic acid-5'-deoxy-adenosine

: 119750-98-0
(3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

Guidance literature:: With tributylphosphine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)88249-1

Reference yield:

: 43077-06-1
6-N-benzoyl-2',3'-O-isopropylideneadenosine-5'-aldehyde

: 119750-98-0
(3aS,4S,6R,6aR)-6-(6-Benzoylamino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: m-CPBA / CH₂Cl₂ / 0.5 h / Ambient temperature

2: N-methylmorpholine / tetrahydrofuran / 0.25 h / 0 °C

3: tetrahydrofuran / 0.5 h / 0 °C

With 4-methyl-morpholine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;