(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-{3-[(E)-(S)-3-hydroxy-4-methyl-5-(2-methyl-thiazol-4-yl)-pent-4-enyl]-phenyl}-4,4,6,8-tetramethyl-5-oxo-nonanoic acid

Base Information

Chemical Name:(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-{3-[(E)-(S)-3-hydroxy-4-methyl-5-(2-methyl-thiazol-4-yl)-pent-4-enyl]-phenyl}-4,4,6,8-tetramethyl-5-oxo-nonanoic acid
CAS No.:335160-01-5
Molecular Formula:C₄₁H₆₉NO₆SSi₂
Molecular Weight:760.239
Hs Code.:

(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-{3-[(E)-(S)-3-hydroxy-4-methyl-5-(2-methyl-thiazol-4-yl)-pent-4-enyl]-phenyl}-4,4,6,8-tetramethyl-5-oxo-nonanoic acid

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Chemical Property of (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-{3-[(E)-(S)-3-hydroxy-4-methyl-5-(2-methyl-thiazol-4-yl)-pent-4-enyl]-phenyl}-4,4,6,8-tetramethyl-5-oxo-nonanoic acid

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Technology Process of (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-{3-[(E)-(S)-3-hydroxy-4-methyl-5-(2-methyl-thiazol-4-yl)-pent-4-enyl]-phenyl}-4,4,6,8-tetramethyl-5-oxo-nonanoic acid

There total 10 articles about (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-{3-[(E)-(S)-3-hydroxy-4-methyl-5-(2-methyl-thiazol-4-yl)-pent-4-enyl]-phenyl}-4,4,6,8-tetramethyl-5-oxo-nonanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 335159-99-4
(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-{3-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-5-(2-methyl-thiazol-4-yl)-pent-4-enyl]-phenyl}-4,4,6,8-tetramethyl-5-oxo-nonanoic acid

: 335160-01-5
(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-{3-[(E)-(S)-3-hydroxy-4-methyl-5-(2-methyl-thiazol-4-yl)-pent-4-enyl]-phenyl}-4,4,6,8-tetramethyl-5-oxo-nonanoic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;

Reference yield:

: 188899-14-1
(3S,4E)-3-(tert-butyldimethylsilyloxy)-4-methyl-5-(2-methyl-1,3-thiazol-4-yl)pent-4-en-1-ol

: 335160-01-5
(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-{3-[(E)-(S)-3-hydroxy-4-methyl-5-(2-methyl-thiazol-4-yl)-pent-4-enyl]-phenyl}-4,4,6,8-tetramethyl-5-oxo-nonanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: Bu₃P / tetrahydrofuran

2.1: H₂O₂ / tetrahydrofuran

3.1: tetrahydrofuran

4.1: PdCl₂(dppf); NaOH / tetrahydrofuran

5.1: 96 percent / CSA; MeOH / CH₂Cl₂

6.1: 60 percent / TPAP; NMO / CH₂Cl₂; acetonitrile

7.1: LDA / tetrahydrofuran / -78 °C

7.2: tetrahydrofuran / -78 °C

8.1: 2,6-lutidine / CH₂Cl₂

9.1: K₂CO₃; MeOH

10.1: 44 percent / TBAF / tetrahydrofuran

With 2,6-dimethylpyridine; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide; N-methyl-2-indolinone; tetrapropylammonium perruthennate; tributylphosphine; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetonitrile; 4.1: Suzuki coupling;

Reference yield:

: 267877-84-9
4-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-penta-1,4-dienyl]-2-methyl-thiazole

: 335160-01-5
(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-{3-[(E)-(S)-3-hydroxy-4-methyl-5-(2-methyl-thiazol-4-yl)-pent-4-enyl]-phenyl}-4,4,6,8-tetramethyl-5-oxo-nonanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran

2.1: PdCl₂(dppf); NaOH / tetrahydrofuran

3.1: 96 percent / CSA; MeOH / CH₂Cl₂

4.1: 60 percent / TPAP; NMO / CH₂Cl₂; acetonitrile

5.1: LDA / tetrahydrofuran / -78 °C

5.2: tetrahydrofuran / -78 °C

6.1: 2,6-lutidine / CH₂Cl₂

7.1: K₂CO₃; MeOH

8.1: 44 percent / TBAF / tetrahydrofuran

With 2,6-dimethylpyridine; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide; N-methyl-2-indolinone; tetrapropylammonium perruthennate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; acetonitrile; 2.1: Suzuki coupling;