[(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionylamino]-acetic acid pentafluorophenyl ester

Base Information

Chemical Name:[(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionylamino]-acetic acid pentafluorophenyl ester
CAS No.:180714-73-2
Molecular Formula:C₂₆H₃₅F₅N₄O₇
Molecular Weight:610.579
Hs Code.:

[(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionylamino]-acetic acid pentafluorophenyl ester

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Chemical Property of [(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionylamino]-acetic acid pentafluorophenyl ester

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Technology Process of [(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionylamino]-acetic acid pentafluorophenyl ester

There total 7 articles about [(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionylamino]-acetic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 180714-73-2
[(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionylamino]-acetic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / N,N-diisopropylethylamine, bis(2-oxooxazolidine-3-yl)phosphinic chloride / CH₂Cl₂ / Ambient temperature

2: 97 percent / H₂ / methanol

3: 84 percent / N,N-diisopropylethylamine, bis(2-oxooxazolidin-3-yl)phosphinic chloride / CH₂Cl₂ / Ambient temperature

4: 98 percent / H₂ / Pd/C / methanol

5: 53 percent / N,N-diisopropylethylamine, bis(2-oxooxazolidin-3-yl)phosphinic chloride / CH₂Cl₂ / 48 h / -15 - -5 °C

6: 97 percent / H₂ / Pd/C / methanol

7: 8.0 g / pyridine / 0 - 25 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane;
DOI:10.1002/hlca.19960790303

Reference yield:

: 65365-33-5
Boc-Leu-Sar-OH

: 180714-73-2
[(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionylamino]-acetic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / N,N-diisopropylethylamine, bis(2-oxooxazolidin-3-yl)phosphinic chloride / CH₂Cl₂ / Ambient temperature

2: 98 percent / H₂ / Pd/C / methanol

3: 53 percent / N,N-diisopropylethylamine, bis(2-oxooxazolidin-3-yl)phosphinic chloride / CH₂Cl₂ / 48 h / -15 - -5 °C

4: 97 percent / H₂ / Pd/C / methanol

5: 8.0 g / pyridine / 0 - 25 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane;
DOI:10.1002/hlca.19960790303

Reference yield:

: 147864-45-7
Boc-Leu-Sar-OCH₂Ph

: 180714-73-2
[(R)-2-({2-[((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-methyl-amino]-acetyl}-methyl-amino)-propionylamino]-acetic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / H₂ / methanol

2: 84 percent / N,N-diisopropylethylamine, bis(2-oxooxazolidin-3-yl)phosphinic chloride / CH₂Cl₂ / Ambient temperature

3: 98 percent / H₂ / Pd/C / methanol

4: 53 percent / N,N-diisopropylethylamine, bis(2-oxooxazolidin-3-yl)phosphinic chloride / CH₂Cl₂ / 48 h / -15 - -5 °C

5: 97 percent / H₂ / Pd/C / methanol

6: 8.0 g / pyridine / 0 - 25 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane;
DOI:10.1002/hlca.19960790303