(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide

Base Information

• Chemical Name: (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide
• CAS No.: 1610546-00-3
• Molecular Formula: C₁₉H₁₃F₈N₅OS₂
• Molecular Weight: 543.464

Synonyms:

Chemical Property of (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide

Chemical Property:

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Safty Information:

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Useful:

Technology Process of (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide

There total 6 articles about (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)benzyl](methyl)oxido-λ⁶-sulfanylidene}cyanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ6-sulfanyl)benzyl](methyl)-λ4-sulfanylidene}cyanamide (1610546-34-3) → (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ6-sulfanyl)benzyl](methyl)oxido-λ6-sulfanylidene}cyanamide (1610546-00-3,1610607-31-2,1610607-32-3)

Guidance literature:

With potassium permanganate; In acetone; at 40 ℃; for 1h; under 112511 Torr;

Reference yield:

[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ6-sulfanyl)phenyl]methanol (1604819-37-5) → (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ6-sulfanyl)benzyl](methyl)oxido-λ6-sulfanylidene}cyanamide (1610546-00-3,1610607-31-2,1610607-32-3)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / dichloromethane / 3 h / 0 - 25 °C

2: ethanol / -15 - 20 °C

3: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / methanol / 1 h / 0 °C

4: potassium permanganate / acetone / 1 h / 40 °C / 112511 Torr

With potassium permanganate; thionyl chloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In methanol; ethanol; dichloromethane; acetone;

Reference yield:

N-[3-(chloromethyl)-5-(pentafluoro-λ6-sulfanyl)phenyl]-4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-amine (1604819-38-6) → (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ6-sulfanyl)benzyl](methyl)oxido-λ6-sulfanylidene}cyanamide (1610546-00-3,1610607-31-2,1610607-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / -15 - 20 °C

2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / methanol / 1 h / 0 °C

3: potassium permanganate / acetone / 1 h / 40 °C / 112511 Torr

With potassium permanganate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In methanol; ethanol; acetone;

upstream raw materials:

[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)phenyl]methanol

N-[3-(chloromethyl)-5-(pentafluoro-λ⁶-sulfanyl)phenyl]-4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-amine

4-(2,4-difluorophenyl)-5-fluoro-N-{3-[(methylsulfanyl)methyl]-5-(pentafluoro-λ⁶-sulfanyl)phenyl}pyrimidin-2-amine

(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(pentafluoro-λ⁶-sulfanyl)benzyl](methyl)-λ⁴-sulfanylidene}cyanamide

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