{4-[((S)-1-{(S)-2-[(S)-1-(4-Hydroxy-benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-methoxy]-phenoxy}-acetic acid tert-butyl ester

Base Information

Chemical Name:{4-[((S)-1-{(S)-2-[(S)-1-(4-Hydroxy-benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-methoxy]-phenoxy}-acetic acid tert-butyl ester
CAS No.:437756-34-8
Molecular Formula:C₃₆H₄₆N₄O₁₀
Molecular Weight:694.782
Hs Code.:

{4-[((S)-1-{(S)-2-[(S)-1-(4-Hydroxy-benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-methoxy]-phenoxy}-acetic acid tert-butyl ester

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Chemical Property of {4-[((S)-1-{(S)-2-[(S)-1-(4-Hydroxy-benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-methoxy]-phenoxy}-acetic acid tert-butyl ester

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Technology Process of {4-[((S)-1-{(S)-2-[(S)-1-(4-Hydroxy-benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-methoxy]-phenoxy}-acetic acid tert-butyl ester

There total 9 articles about {4-[((S)-1-{(S)-2-[(S)-1-(4-Hydroxy-benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-methoxy]-phenoxy}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 47450-18-0,68166-40-5,53331-43-4
N-benzyloxycarbonyl-L-valyl-L-proline

: 437756-34-8
{4-[((S)-1-{(S)-2-[(S)-1-(4-Hydroxy-benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-methoxy]-phenoxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: WSC; pyridine

2: H₂ / Pd(OH)2 / ethyl acetate

3: WSC; pyridine

4: Dess-Martin periodinane / CH₂Cl₂

5: TBAF / tetrahydrofuran

With pyridine; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(01)00797-1

Reference yield:

: 437756-10-0
2-amino-1-[4-(tert-butyl-dimethyl-silanyloxy)-benzooxazol-2-yl]-3-methyl-butan-1-ol

: 437756-34-8
{4-[((S)-1-{(S)-2-[(S)-1-(4-Hydroxy-benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-methoxy]-phenoxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: WSC; pyridine

2: H₂ / Pd(OH)2 / ethyl acetate

3: WSC; pyridine

4: Dess-Martin periodinane / CH₂Cl₂

5: TBAF / tetrahydrofuran

With pyridine; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(01)00797-1

Reference yield:

: 437755-82-3
{(S)-1-[Hydroxy-(4-hydroxy-benzooxazol-2-yl)-methyl]-2-methyl-propyl}-carbamic acid benzyl ester

: 437756-34-8
{4-[((S)-1-{(S)-2-[(S)-1-(4-Hydroxy-benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-methoxy]-phenoxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: DMAP; Et₃N / CH₂Cl₂

2: Des-Martin periodinane / CH₂Cl₂

3: H₂ / Pd(OH)2 / ethyl acetate

4: WSC; pyridine

5: H₂ / Pd(OH)2 / ethyl acetate

6: WSC; pyridine

7: Dess-Martin periodinane / CH₂Cl₂

8: TBAF / tetrahydrofuran

With pyridine; dmap; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(01)00797-1