(E)-(2R,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

Base Information

Chemical Name:(E)-(2R,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester
CAS No.:205692-03-1
Molecular Formula:C₃₁H₄₁NO₅S
Molecular Weight:539.736
Hs Code.:

(E)-(2R,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(2R,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

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Technology Process of (E)-(2R,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

There total 3 articles about (E)-(2R,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 205692-03-1
(E)-(2R,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 96 percent / pyridine / CH₂Cl₂

3: 1.) n-Bu₂BOTf, i-Pr₂NEt / 1.) CH₂Cl₂, -78 deg C, 2 h, 2.) CH₂Cl₂, -78 deg C, 1 h, 0 deg C, 1 h

With pyridine; di-n-butylboryl trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0040-4039(98)00123-3

Reference yield:

: 130881-18-4
1,2,3,4,5,6,7,8-octahydro-9-anthracenesulfonyl chloride

: 205692-03-1
(E)-(2R,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 96 percent / pyridine / CH₂Cl₂

3: 1.) n-Bu₂BOTf, i-Pr₂NEt / 1.) CH₂Cl₂, -78 deg C, 2 h, 2.) CH₂Cl₂, -78 deg C, 1 h, 0 deg C, 1 h

With pyridine; di-n-butylboryl trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0040-4039(98)00123-3

Reference yield:

: 123-73-9,4170-30-3
trans-Crotonaldehyde

: 205691-90-3
(1R,2S)-2-(N-methyl-N-(1,2,3,4,5,6,7,8-octahydro-9-anthracenesulfonyl)amino)-1-phenyl-1-propyl propionate

: 205692-04-2
(E)-(2R,3R)-3-Hydroxy-2-methyl-hex-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

: 205692-03-1
(E)-(2R,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid (1R,2S)-2-[methyl-(1,2,3,4,5,6,7,8-octahydro-anthracene-9-sulfonyl)-amino]-1-phenyl-propyl ester

Guidance literature:: With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, -78 deg C, 2 h, 2.) CH₂Cl₂, -78 deg C, 1 h, 0 deg C, 1 h;
DOI:10.1016/S0040-4039(98)00123-3