Technology Process of (2R,3R,4S,5R,6R)-7-Benzyloxy-2-((R)-1-benzyloxymethoxy-propyl)-4,6-dimethyl-heptane-1,3,5-triol
There total 12 articles about (2R,3R,4S,5R,6R)-7-Benzyloxy-2-((R)-1-benzyloxymethoxy-propyl)-4,6-dimethyl-heptane-1,3,5-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 84 percent / diethyl ether / -30 °C
2: NaH / tetrahydrofuran / Heating
3: DMAP, DCC
4: O3, Me2S / methanol; CH2Cl2 / -78 °C
5: diethyl ether / -78 °C
6: 88 percent / CF3CO2H / benzene / Heating
8: 1.) BH3*THF, 2.) H2O2 / 1.) THF, -78 deg C to 0 deg C, 2.) aq. NaOH
9: i-Pr2NEt / CH2Cl2
10: 1.) n-PrSLi / 1.) HMPA, 25 deg C, 2.) THF-HOAc, 25 deg C
11: 1.) LiBH4, 2.) n-Bu4NF / 1.) THF, 25 deg C, 2.) THF
With
dmap; lithium borohydride; borane-THF; dimethylsulfide; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium hydride; lithium n-propylmercaptide; ozone; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(00)95562-X
- Guidance literature:
-
Multi-step reaction with 10 steps
1: NaH / tetrahydrofuran / Heating
2: DMAP, DCC
3: O3, Me2S / methanol; CH2Cl2 / -78 °C
4: diethyl ether / -78 °C
5: 88 percent / CF3CO2H / benzene / Heating
7: 1.) BH3*THF, 2.) H2O2 / 1.) THF, -78 deg C to 0 deg C, 2.) aq. NaOH
8: i-Pr2NEt / CH2Cl2
9: 1.) n-PrSLi / 1.) HMPA, 25 deg C, 2.) THF-HOAc, 25 deg C
10: 1.) LiBH4, 2.) n-Bu4NF / 1.) THF, 25 deg C, 2.) THF
With
dmap; lithium borohydride; borane-THF; dimethylsulfide; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium hydride; lithium n-propylmercaptide; ozone; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(00)95562-X
- Guidance literature:
-
Multi-step reaction with 9 steps
1: DMAP, DCC
2: O3, Me2S / methanol; CH2Cl2 / -78 °C
3: diethyl ether / -78 °C
4: 88 percent / CF3CO2H / benzene / Heating
6: 1.) BH3*THF, 2.) H2O2 / 1.) THF, -78 deg C to 0 deg C, 2.) aq. NaOH
7: i-Pr2NEt / CH2Cl2
8: 1.) n-PrSLi / 1.) HMPA, 25 deg C, 2.) THF-HOAc, 25 deg C
9: 1.) LiBH4, 2.) n-Bu4NF / 1.) THF, 25 deg C, 2.) THF
With
dmap; lithium borohydride; borane-THF; dimethylsulfide; tetrabutyl ammonium fluoride; dihydrogen peroxide; lithium n-propylmercaptide; ozone; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(00)95562-X
