diphenylmethyl 5-cyano-8,11-dioxo-9,10-epoxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,9,10,11,12,12a-dodecahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

Base Information

Chemical Name:diphenylmethyl 5-cyano-8,11-dioxo-9,10-epoxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,9,10,11,12,12a-dodecahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate
CAS No.:133507-72-9
Molecular Formula:C₃₁H₂₉N₃O₆
Molecular Weight:539.588
Hs Code.:

diphenylmethyl 5-cyano-8,11-dioxo-9,10-epoxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,9,10,11,12,12a-dodecahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

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Chemical Property of diphenylmethyl 5-cyano-8,11-dioxo-9,10-epoxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,9,10,11,12,12a-dodecahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

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Technology Process of diphenylmethyl 5-cyano-8,11-dioxo-9,10-epoxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,9,10,11,12,12a-dodecahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

There total 4 articles about diphenylmethyl 5-cyano-8,11-dioxo-9,10-epoxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,9,10,11,12,12a-dodecahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.9%

: 115315-10-1
diphenylmethyl 5-cyano-8,11-dioxo-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,11,12,12a-decahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

: 133507-72-9,133576-58-6
diphenylmethyl 5-cyano-8,11-dioxo-9,10-epoxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,9,10,11,12,12a-dodecahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

Guidance literature:: With sodium hypochlorite; In 1,4-dioxane;
DOI:10.1248/cpb.38.3202

Reference yield:

: 115362-83-9
4-cyano-7-hydroxy-6-hydroxymethyl-3,12-imino-13-methyl-1,2,3,4,6,11,11a,12-octahydroazepino<1,2-b>isoquinoline-1-carboxylic acid

: 133507-72-9,133576-58-6
diphenylmethyl 5-cyano-8,11-dioxo-9,10-epoxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,9,10,11,12,12a-dodecahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / CHCl₃; methanol / 1 h

2: 78.8 percent / Fremy's salt, 1N AcONa / acetonitrile

3: 48.9 percent / aq. NaOCl / dioxane

With sodium hypochlorite; potassiuim nitrosodisulfonate; sodium acetate; In 1,4-dioxane; methanol; chloroform; acetonitrile;
DOI:10.1248/cpb.38.3202

Reference yield:

: 115315-09-8
diphenylmethyl 5-cyano-8-hydroxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,12,12a-octahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

: 133507-72-9,133576-58-6
diphenylmethyl 5-cyano-8,11-dioxo-9,10-epoxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,9,10,11,12,12a-dodecahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 78.8 percent / Fremy's salt, 1N AcONa / acetonitrile

2: 48.9 percent / aq. NaOCl / dioxane

With sodium hypochlorite; potassiuim nitrosodisulfonate; sodium acetate; In 1,4-dioxane; acetonitrile;
DOI:10.1248/cpb.38.3202