Technology Process of (1S,4R)-3-[2-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-methyl-cyclohexanol
There total 12 articles about (1S,4R)-3-[2-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-methyl-cyclohexanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 70 percent / DIBAL / hexane; benzene / 0.5 h / 0 °C
2: 55 percent / tert-butyl hydroperoxide, vanadyl acetoacetate / 24 h / Ambient temperature
3: 95 percent / PDC / dimethylformamide / 6 h / 0 °C
4: 50 percent / Al/Hg, NaHCO3 / ethanol
5: 1.) n-BuLi / 1.) THF, hexane, RT, 5 min, 2.) THF, hexane, RT, 1 h
6: 40percent HF / acetonitrile / 0.5 h
7: 100 percent / LiAlH4 / diethyl ether / 1 h / 0 °C
8: LiAlH4, TiCl3 / diethyl ether; tetrahydrofuran / 1 h / Heating
With
tert.-butylhydroperoxide; aluminum amalgam; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; titanium(III) chloride; vanadyl acetoacetonate; hydrogen fluoride; diisobutylaluminium hydride; sodium hydrogencarbonate;
In
tetrahydrofuran; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo00392a012
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 55 percent / tert-butyl hydroperoxide, vanadyl acetoacetate / 24 h / Ambient temperature
2: 95 percent / PDC / dimethylformamide / 6 h / 0 °C
3: 50 percent / Al/Hg, NaHCO3 / ethanol
4: 1.) n-BuLi / 1.) THF, hexane, RT, 5 min, 2.) THF, hexane, RT, 1 h
5: 40percent HF / acetonitrile / 0.5 h
6: 100 percent / LiAlH4 / diethyl ether / 1 h / 0 °C
7: LiAlH4, TiCl3 / diethyl ether; tetrahydrofuran / 1 h / Heating
With
tert.-butylhydroperoxide; aluminum amalgam; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; titanium(III) chloride; vanadyl acetoacetonate; hydrogen fluoride; sodium hydrogencarbonate;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00392a012
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-BuLi / 1.) THF, hexane, RT, 5 min, 2.) THF, hexane, RT, 1 h
2: 40percent HF / acetonitrile / 0.5 h
3: 100 percent / LiAlH4 / diethyl ether / 1 h / 0 °C
4: LiAlH4, TiCl3 / diethyl ether; tetrahydrofuran / 1 h / Heating
With
lithium aluminium tetrahydride; n-butyllithium; titanium(III) chloride; hydrogen fluoride;
In
tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1021/jo00392a012
