C₂₈H₂₁N₅O₂

Base Information

• Chemical Name: C₂₈H₂₁N₅O₂
• CAS No.: 1305330-26-0
• Molecular Formula: C₂₈H₂₁N₅O₂
• Molecular Weight: 459.507
• Mol file: 1305330-26-0.mol

Synonyms:

Chemical Property of C₂₈H₂₁N₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₁N₅O₂

There total 3 articles about C₂₈H₂₁N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C22H21NO2 (1305330-16-8) + ethenetetracarbonitrile (670-54-2) → C28H21N5O2 (1305330-26-0)

Guidance literature:

In ethyl acetate; for 1h; Reflux; Inert atmosphere;

DOI:10.1002/chem.201003628

Reference yield:

5-isopropyl-2H-cyclohepta[b]furan-2-one (100748-51-4) → C28H21N5O2 (1305330-26-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N-iodo-succinimide / dichloromethane / 0.67 h / 20 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

3: ethyl acetate / 1 h / Reflux; Inert atmosphere

With N-iodo-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; 2: Sonogashira coupling;

DOI:10.1002/chem.201003628

Reference yield:

3-iodo-5-isopropyl-2H-cyclohepta[b]furan-2-one (1305330-11-3) + 4-ethynyl-N,N-dimethylaniline (17573-94-3,752235-18-0) → C28H21N5O2 (1305330-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

2: ethyl acetate / 1 h / Reflux; Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; ethyl acetate; 1: Sonogashira coupling;

DOI:10.1002/chem.201003628

upstream raw materials:

C₂₂H₂₁NO₂

ethenetetracarbonitrile

3-iodo-5-isopropyl-2H-cyclohepta[b]furan-2-one

4-ethynyl-N,N-dimethylaniline