N-(4-(1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)-4-propylbenzamide

Base Information

Chemical Name:N-(4-(1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)-4-propylbenzamide
CAS No.:1323206-59-2
Molecular Formula:C₂₉H₂₇F₂N₇O₃
Molecular Weight:559.575
Hs Code.:

Synonyms:

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Chemical Property of N-(4-(1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)-4-propylbenzamide

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Technology Process of N-(4-(1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)-4-propylbenzamide

There total 4 articles about N-(4-(1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)-4-propylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312809-89-4
1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-nitrophenyl)-1H-1,2,4-triazol-5(4H)-one

: 1323206-59-2
N-(4-(1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)-4-propylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / 4 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmcl.2011.06.008

Reference yield:

: 278783-69-0
4-(4-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1323206-59-2
N-(4-(1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)-4-propylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 6 h / 80 °C

2: palladium 10% on activated carbon; hydrogen / 4 h / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmcl.2011.06.008

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 1323206-59-2
N-(4-(1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)-4-propylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate; toluene-4-sulfonic acid; trimethyl orthoformate / methanol / 5 h / Reflux

2: potassium carbonate / 6 h / 80 °C

3: palladium 10% on activated carbon; hydrogen / 4 h / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 6 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; sodium methylate; potassium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trimethyl orthoformate; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.06.008