N-[2-(2-{2,5-difluoro-4-[4-((S)-2-hydroxypropyl)piperazin-1-yl]phenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide trifluoroacetic acid

Base Information

Chemical Name:N-[2-(2-{2,5-difluoro-4-[4-((S)-2-hydroxypropyl)piperazin-1-yl]phenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide trifluoroacetic acid
CAS No.:1353898-62-0
Molecular Formula:C₂HF₃O₂*C₂₇H₃₁F₂N₇O₃S
Molecular Weight:685.675
Hs Code.:

N-[2-(2-{2,5-difluoro-4-[4-((S)-2-hydroxypropyl)piperazin-1-yl]phenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide trifluoroacetic acid

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Chemical Property of N-[2-(2-{2,5-difluoro-4-[4-((S)-2-hydroxypropyl)piperazin-1-yl]phenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide trifluoroacetic acid

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Technology Process of N-[2-(2-{2,5-difluoro-4-[4-((S)-2-hydroxypropyl)piperazin-1-yl]phenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide trifluoroacetic acid

There total 6 articles about N-[2-(2-{2,5-difluoro-4-[4-((S)-2-hydroxypropyl)piperazin-1-yl]phenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂HF₃O₂*C₁₃H₁₇F₂N₃O₃

: 1353898-62-0
N-[2-(2-{2,5-difluoro-4-[4-((S)-2-hydroxypropyl)piperazin-1-yl]phenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol

2: 85 °C

With palladium on activated charcoal; hydrogen; In methanol;
DOI:10.1021/jm2010767

Reference yield:

: 1233143-37-7
C₁₄H₁₄N₄O₃S

: 1353898-62-0
N-[2-(2-{2,5-difluoro-4-[4-((S)-2-hydroxypropyl)piperazin-1-yl]phenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: 85 °C

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm2010767

Reference yield:

: 1233185-03-9
C₂HF₃O₂*C₁₀H₁₁F₂N₃O₂

: 1353898-62-0
N-[2-(2-{2,5-difluoro-4-[4-((S)-2-hydroxypropyl)piperazin-1-yl]phenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: methanol

2: palladium on activated charcoal; hydrogen / methanol

3: 85 °C

With palladium on activated charcoal; hydrogen; In methanol;
DOI:10.1021/jm2010767