(R)-2-amino-N-methyl-2-phenylacetamide

Base Information

Chemical Name:(R)-2-amino-N-methyl-2-phenylacetamide
CAS No.:95523-35-6
Molecular Formula:C₉H₁₂N₂O
Molecular Weight:164.207
Hs Code.:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-amino-N-methyl-2-phenylacetamide

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Technology Process of (R)-2-amino-N-methyl-2-phenylacetamide

There total 6 articles about (R)-2-amino-N-methyl-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: (R)-2,2,3-trimethyl-5-phenylimidazolidin-4-one

: 93782-07-1,95523-35-6,129213-83-8,97549-10-5
(R)-2-amino-N-methyl-2-phenylacetamide

Guidance literature:: With hydrogenchloride; acetic acid; In water; toluene; at 100 ℃; for 1h; Microwave irradiation;
DOI:10.1039/c7cc01561e

Reference yield: 45.0%

: (R)-2-methyl-4-phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide

: 93782-07-1,95523-35-6,129213-83-8,97549-10-5
(R)-2-amino-N-methyl-2-phenylacetamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.166667h; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1039/c6ob02655a

Reference yield:

: 1,2,2-trimethyl-4-phenyl-1H-imidazol-5(2H)-one

: 93782-07-1,95523-35-6,129213-83-8,97549-10-5
(R)-2-amino-N-methyl-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: ((2R,2'R)-1'-(2-hydroxybenzyl)-[2,2'-bipyrrolidin]-1-yl)(pyridin-2-yl)methanon; acetic acid; trichlorosilane / chloroform / 24 h / 20 °C

2: hydrogenchloride; acetic acid / water; toluene / 1 h / 100 °C / Microwave irradiation

With hydrogenchloride; trichlorosilane; ((2R,2'R)-1'-(2-hydroxybenzyl)-[2,2'-bipyrrolidin]-1-yl)(pyridin-2-yl)methanon; acetic acid; In chloroform; water; toluene;
DOI:10.1039/c7cc01561e