(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-4-carboxy-butyrylamino]-3-methyl-butyrylamino}-3-methyl-butyrylamino)-pentanedioic acid

Base Information

• Chemical Name: (S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-4-carboxy-butyrylamino]-3-methyl-butyrylamino}-3-methyl-butyrylamino)-pentanedioic acid
• CAS No.: 127290-75-9
• Molecular Formula: C₄₂H₅₈N₆O₁₄
• Molecular Weight: 870.954
• Mol file: 127290-75-9.mol

Synonyms:

Chemical Property of (S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-4-carboxy-butyrylamino]-3-methyl-butyrylamino}-3-methyl-butyrylamino)-pentanedioic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-4-carboxy-butyrylamino]-3-methyl-butyrylamino}-3-methyl-butyrylamino)-pentanedioic acid

There total 10 articles about (S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-4-carboxy-butyrylamino]-3-methyl-butyrylamino}-3-methyl-butyrylamino)-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-nitrophenyl N2,N6-bis[(phenylmethoxy)carbonyl]-L-lysinate (21160-82-7) + Glutamyl-valyl-valyl-glutamic Acid (78603-90-4) → (S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-4-carboxy-butyrylamino]-3-methyl-butyrylamino}-3-methyl-butyrylamino)-pentanedioic acid (127290-75-9)

Guidance literature:

With sodium hydroxide;

Reference yield:

N-L-valyl-L-glutamic acid (3062-07-5) → (S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-4-carboxy-butyrylamino]-3-methyl-butyrylamino}-3-methyl-butyrylamino)-pentanedioic acid (127290-75-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / 1 N NaOH / 48 h

2: hydrogen / Pd-C / acetic acid; methanol

3: 65 percent / 1 N NaOH

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; acetic acid;

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → (S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2,6-Bis-benzyloxycarbonylamino-hexanoylamino)-4-carboxy-butyrylamino]-3-methyl-butyrylamino}-3-methyl-butyrylamino)-pentanedioic acid (127290-75-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 91 percent / 1 N NaOH / dioxane / 48 h / Ambient temperature

2: 77 percent / dioxane / 3 h / Ambient temperature

3: 56 percent / 1 N NaOH / 48 h

4: hydrogen / Pd-C / acetic acid; methanol

5: 65 percent / 1 N NaOH

With sodium hydroxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; acetic acid;

upstream raw materials:

4-nitrophenyl N₂,N₆-bis[(phenylmethoxy)carbonyl]-L-lysinate

Glutamyl-valyl-valyl-glutamic Acid

N-L-valyl-L-glutamic acid

L-valine