Technology Process of 6,7-Bis-benzyloxy-5-trifluoromethyl-1-(3,4,5-trimethoxy-benzyl)-3,4-dihydro-isoquinoline
There total 11 articles about 6,7-Bis-benzyloxy-5-trifluoromethyl-1-(3,4,5-trimethoxy-benzyl)-3,4-dihydro-isoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trichlorophosphate;
In
acetonitrile;
for 5h;
Heating;
DOI:10.1021/jm00081a007
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 73 percent / pyridine, iodine monochloride / dioxane / 144 h / Ambient temperature
2: 85 percent / potassium carbonate / acetone / 6 h / Heating
3: 40 percent / cuprous iodide / various solvent(s) / 4 h / 175 °C
4: 87 percent / sodium borohydride / tetrahydrofuran; H2O / 2.5 h / 40 °C
5: 73.5 percent / phosphorus tribromide / CH2Cl2 / 2 h / 0 °C
6: 92 percent / dimethylformamide / 0.5 h / Ambient temperature
7: 82 percent / boron tribromide / CH2Cl2 / Ambient temperature
8: 86 percent / potassium carbonate, potassium iodide / acetone / Heating
9: diborane / tetrahydrofuran / Heating
10: toluene / 72 h / Heating
11: phosphorus oxychloride / acetonitrile / 5 h / Heating
With
pyridine; sodium tetrahydroborate; copper(l) iodide; Iodine monochloride; boron tribromide; phosphorus tribromide; potassium carbonate; potassium iodide; diborane; trichlorophosphate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/jm00081a007
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 40 percent / cuprous iodide / various solvent(s) / 4 h / 175 °C
2: 87 percent / sodium borohydride / tetrahydrofuran; H2O / 2.5 h / 40 °C
3: 73.5 percent / phosphorus tribromide / CH2Cl2 / 2 h / 0 °C
4: 92 percent / dimethylformamide / 0.5 h / Ambient temperature
5: 82 percent / boron tribromide / CH2Cl2 / Ambient temperature
6: 86 percent / potassium carbonate, potassium iodide / acetone / Heating
7: diborane / tetrahydrofuran / Heating
8: toluene / 72 h / Heating
9: phosphorus oxychloride / acetonitrile / 5 h / Heating
With
sodium tetrahydroborate; copper(l) iodide; boron tribromide; phosphorus tribromide; potassium carbonate; potassium iodide; diborane; trichlorophosphate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/jm00081a007
