Technology Process of Benzeneacetic acid, a-cyclobutyl-a-methyl-
There total 6 articles about Benzeneacetic acid, a-cyclobutyl-a-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol;
for 14h;
Heating;
DOI:10.1021/jo00282a020
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 71 percent / silver nitrate, sodium hydroxide / H2O; ethanol / 24 h / Ambient temperature
2: thionyl chloride, pyridine / benzene / 6 h / Ambient temperature
3: 2 h
4: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 15 min, 2.) from -30 deg C to 0 deg C
5: 91 percent / potassium hydroxide / methanol / 14 h / Heating
With
pyridine; potassium hydroxide; sodium hydroxide; thionyl chloride; silver nitrate; lithium diisopropyl amide;
In
methanol; ethanol; water; benzene;
DOI:10.1021/jo00282a020
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride, pyridine / benzene / 6 h / Ambient temperature
2: 2 h
3: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 15 min, 2.) from -30 deg C to 0 deg C
4: 91 percent / potassium hydroxide / methanol / 14 h / Heating
With
pyridine; potassium hydroxide; thionyl chloride; lithium diisopropyl amide;
In
methanol; benzene;
DOI:10.1021/jo00282a020
