3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:123195-24-4
Molecular Formula:C20H20FN3O3S
Molecular Weight:401.462
Hs Code.:
DSSTox Substance ID:DTXSID201126788
Nikkaji Number:J449.596I
Mol file:123195-24-4.mol

Synonyms:SCHEMBL10491218;DTXSID201126788;123195-24-4;L003340;3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Suppliers and Price of 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:401.12094084
Heavy Atom Count:28
Complexity:618

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=C(C=CS4)NC3=O

Technology Process of 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

There total 4 articles about 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: N-(2-carbomethoxythien-3-yl)-N'-<2-<4-(4-fluorobenzoyl)piperidin-1-yl>ethyl>urea

: 123195-24-4
3-<2-<4-(4-fluorobenzoyl)piperidin-1-yl>ethyl>thieno<3,2-d>pyrimidine-2,4-dione

Guidance literature:: With sodium hydroxide; In methanol; for 24h; Ambient temperature;
DOI:10.1016/0223-5234(91)90007-A

Reference yield: 62.0%

: N-(2-carbomethoxythien-3-yl)-N-(2-chloroethyl)urea

: 25519-78-2
4-(4-fluorobenzoyl)piperidine hydrochloride

: N-(2-carbomethoxythien-3-yl)-N-[2-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]urea

: 123195-24-4
3-<2-<4-(4-fluorobenzoyl)piperidin-1-yl>ethyl>thieno<3,2-d>pyrimidine-2,4-dione

Guidance literature:: With sodium iodide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 25519-78-2
4-(4-fluorobenzoyl)piperidine hydrochloride

: 123195-24-4
3-<2-<4-(4-fluorobenzoyl)piperidin-1-yl>ethyl>thieno<3,2-d>pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / NaHCO₃, NaI / tetrahydrofuran / 96 h / Heating

2: 94 percent / 50percent NaOH / methanol / 24 h / Ambient temperature

With sodium hydroxide; sodium hydrogencarbonate; sodium iodide; In tetrahydrofuran; methanol;
DOI:10.1016/0223-5234(91)90007-A