Thieno[3,4-d]pyrimidine-2,4(1H,3H)-dione, 1-(2,2-dimethyl-1-oxopropyl)-3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl ]-

Base Information

Chemical Name:Thieno[3,4-d]pyrimidine-2,4(1H,3H)-dione, 1-(2,2-dimethyl-1-oxopropyl)-3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl ]-
CAS No.:123213-68-3
Molecular Formula:C₂₅H₂₈FN₃O₄S
Molecular Weight:485.579
Hs Code.:
Mol file:123213-68-3.mol

Synonyms:

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Chemical Property of Thieno[3,4-d]pyrimidine-2,4(1H,3H)-dione, 1-(2,2-dimethyl-1-oxopropyl)-3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl ]-

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Technology Process of Thieno[3,4-d]pyrimidine-2,4(1H,3H)-dione, 1-(2,2-dimethyl-1-oxopropyl)-3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl ]-

There total 3 articles about Thieno[3,4-d]pyrimidine-2,4(1H,3H)-dione, 1-(2,2-dimethyl-1-oxopropyl)-3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl ]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25519-78-2
4-(4-fluorobenzoyl)piperidine hydrochloride

: 123213-68-3
1-(2,2-Dimethyl-propionyl)-3-{2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-ethyl}-1H-thieno[3,4-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃, NaI / tetrahydrofuran / 96 h / Heating

2: 50percent NaOH / methanol / 24 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

With sodium hydroxide; sodium hydrogencarbonate; triethylamine; sodium iodide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0223-5234(91)90007-A

Reference yield:

: 110164-47-1
N-(3-carbomethoxythien-4-yl)-N'-(2-chloroethyl)urea

: 123213-68-3
1-(2,2-Dimethyl-propionyl)-3-{2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-ethyl}-1H-thieno[3,4-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃, NaI / tetrahydrofuran / 96 h / Heating

2: 50percent NaOH / methanol / 24 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

With sodium hydroxide; sodium hydrogencarbonate; triethylamine; sodium iodide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0223-5234(91)90007-A

Reference yield:

: 4-(3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-ureido)-thiophene-3-carboxylic acid methyl ester

: 123213-68-3
1-(2,2-Dimethyl-propionyl)-3-{2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-ethyl}-1H-thieno[3,4-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 50percent NaOH / methanol / 24 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

With sodium hydroxide; triethylamine; In methanol; dichloromethane;
DOI:10.1016/0223-5234(91)90007-A